RAB35 RAB35, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB35provided by HGNC
Official Full Name: RAB35, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9774
See related: Ensembl:ENSG00000111737 MIM:604199; AllianceGenome:HGNC:9774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAY; H-ray; RAB1C
Summary: Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen (RPKM 16.4), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (120095099..120116753, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (120082260..120103928, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120532903..120554557, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35.
Title: A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35.
This reference shows that the oxidoreductase MICAL1 is an effector of Rab35 during cytokinesis.
Title: Oxidation of F-actin controls the terminal steps of cytokinesis.
This reference shows that MiniBAR/GARRE1 is a dual Rab35 and Rac1 effector during ciliogenesis.
Title: MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis.
DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.
Title: DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.
Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.
Title: Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.
BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.
Title: BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.
Transcellular propagation of fibrillar alpha-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.
Title: Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.
Rab35 regulates insulin secretion via phogrin in pancreatic beta cells.
Title: Rab35 regulates insulin secretion via phogrin in pancreatic β cells.
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
Title: Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
Title: MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of RAB35, member RAS oncogene family by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G29084 (e-PCR)
- UniSTS:53284

RH98593 (e-PCR)
- UniSTS:91486

RAB35_771 (e-PCR)
- UniSTS:277640

WI-16071 (e-PCR)
- UniSTS:80284

RH91346 (e-PCR)
- UniSTS:87206

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed
located_in intercellular bridge	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ras-related protein Rab-35

Names: GTP-binding protein RAY; ras-related protein rab-1c (GTP-binding protein ray)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167606.2 → NP_001161078.1 ras-related protein Rab-35 isoform 2

See identical proteins and their annotated locations for NP_001161078.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 2.

Source sequence(s)

AK001309, AK304620, BP303346, DC370610

Consensus CDS

CCDS53836.1

UniProtKB/Swiss-Prot

Q15286

Related

ENSP00000441883.1, ENST00000534951.5

Conserved Domains (1) summary

cl38936
Location:3 → 117

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_006861.7 → NP_006852.1 ras-related protein Rab-35 isoform 1

See identical proteins and their annotated locations for NP_006852.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC004812, AI042456, BC015931

Consensus CDS

CCDS41846.1

UniProtKB/Swiss-Prot

B2R6E0, B4E390, Q15286

Related

ENSP00000229340.5, ENST00000229340.10

Conserved Domains (1) summary

cd04110
Location:3 → 201

Rab35; Rab GTPase family 35 (Rab35)