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    CDR1-AS CDR1 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 103611090, updated on 22-Oct-2024

    Summary

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    Official Symbol
    CDR1-ASprovided by HGNC
    Official Full Name
    CDR1 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:48926
    See related
    MIM:300898
    Gene type
    ncRNA
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIRS7; CDR1as; ciRS-7; CDR1NAT
    Summary
    This gene represents naturally-occurring RNAs transcribed in antisense to CDR1 (cerebellar degeneration-related protein 1, 34kDa; GeneID:1038), some of which may be circular rather than linear. The circular RNA produced by this locus acts as an miRNA sponge, preventing the miRNA from interacting with target transcripts. No RefSeq transcript is created for the circular RNA. [provided by RefSeq, Feb 2024]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    Xq27.1

    Bibliography

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    Related articles in PubMed

    1. Detection and characterization of ciRS-7: a potential promoter of the development of cancer. Zheng XB, et al. Neoplasma, 2017. PMID 28253710
    2. Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway. Liu L, et al. Hepatobiliary Pancreat Dis Int, 2019 Dec. PMID 30898507
    3. Downregulation of CircRNA CDR1as specifically triggered low-dose Diosbulbin-B induced gastric cancer cell death by regulating miR-7-5p/REGγ axis. Li C, et al. Biomed Pharmacother, 2019 Dec. PMID 31542615
    4. Circular RNA CDR1-AS contributes to pemetrexed and cisplatin chemoresistance through EGFR/PI3K signaling pathway in lung adenocarcinoma. Mao Y, et al. Biomed Pharmacother, 2020 Mar. PMID 31881486
    5. Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7). Zhao Y, et al. Genes (Basel), 2016 Dec 5. PMID 27929395, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of circRNA CDR1as/miR-214-3p regulatory axis in Legg-Calve-Perthes disease.
      Title: Identification of circRNA CDR1as/miR-214-3p regulatory axis in Legg-Calvé-Perthes disease.
    2. Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.
      Title: Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.
    3. Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium.
      Title: Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium.
    4. CDR1-AS is an oncogene that promotes laryngeal squamous cell carcinoma progression by regulating miR-7 signals
      Title: CDR1as is overexpressed in laryngeal squamous cell carcinoma to promote the tumour's progression via miR-7 signals.
    5. IGF2BP3-mediated melanoma invasion and metastasis is driven by epigenetic silencing of CDR1-AS.
      Title: Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
    6. Circular RNA CDR1-AS Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
      Title: Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
    7. CircRNA CDR1as: a novel diagnostic and prognostic biomarker for gastric cancer.
      Title: CircRNA CDR1as: a novel diagnostic and prognostic biomarker for gastric cancer.
    8. Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells via regulating miR-135a-5p/stat1 axis.
      Title: Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells via regulating miR-135a-5p/stat1 axis.
    9. Circulating expression levels of CircHIPK3 and CDR1as circular-RNAs in type 2 diabetes patients.
      Title: Circulating expression levels of CircHIPK3 and CDR1as circular-RNAs in type 2 diabetes patients.
    10. ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma.
      Title: ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    General gene information

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    Other Names

    • CDR1 natural antisense transcript
    • circular RNA sponge for miR-7

    Clone Names

    • FLJ30359, FLJ37221

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