U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 23072, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HECW1provided by HGNC
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:22195
    See related
    Ensembl:ENSG00000002746 MIM:610384; AllianceGenome:HGNC:22195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDL1
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination; regulation of dendrite morphogenesis; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 3.0), brain (RPKM 2.6) and 3 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HECW1 in Genome Data Viewer
    Location:
    7p14.1-p13
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (43112647..43566001)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43270827..43724047)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43152246..43605600)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43086257-43086757 Neighboring gene Sharpr-MPRA regulatory region 4044 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43098985-43099585 Neighboring gene uncharacterized LOC107986790 Neighboring gene Sharpr-MPRA regulatory region 5110 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43117009-43117801 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:43147486-43148000 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:43157882-43159081 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43178144-43178740 Neighboring gene HECW1 intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43236783-43237295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43237296-43237807 Neighboring gene microRNA 3943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43253900-43254417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43254418-43254934 Neighboring gene RNA, U7 small nuclear 35 pseudogene Neighboring gene RNA, U6 small nuclear 575, pseudogene Neighboring gene uncharacterized LOC124901619 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:43312759-43312902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43333091-43334026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43334027-43334961 Neighboring gene uncharacterized LOC102724903 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43343825-43344325 Neighboring gene ribosomal protein L18a pseudogene 10 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43416277-43416776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43507100-43507600 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:43593671-43594870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18123 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:43616728-43617927 Neighboring gene lncRNA upregulator of antiviral response interferon signaling Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99082 Neighboring gene Sharpr-MPRA regulatory region 11578 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43686409-43687270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43688133-43688994 Neighboring gene Sharpr-MPRA regulatory region 11574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43691438-43692181 Neighboring gene serine/threonine kinase 17a Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18125 Neighboring gene NFE2L2 motif-containing MPRA enhancer 272 Neighboring gene cytochrome c oxidase assembly factor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43768408-43769137 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:43769138-43769866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43789145-43789664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43789665-43790184 Neighboring gene uncharacterized LOC107986727 Neighboring gene CRISPRi-validated cis-regulatory element chr7.1855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18127 Neighboring gene biliverdin reductase A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1. Haouari S, et al. Int J Mol Sci, 2023 Jan 9. PMID 36674783, Free PMC Article
    2. Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy. Liu Y, et al. Ren Fail, 2019 Nov. PMID 31057023, Free PMC Article
    3. Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma. Wang C, et al. BMC Cancer, 2021 Aug 4. PMID 34348693, Free PMC Article
    4. Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice. Zhang L, et al. J Biomed Biotechnol, 2011. PMID 20976258, Free PMC Article
    5. The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. Liu J, et al. Cell Signal, 2019 Jun. PMID 30849519, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350.
      Title: HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350.
    2. Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1.
      Title: Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1.
    3. E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.
      Title: E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.
    4. Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma.
      Title: Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma.
    5. The ubiquitin E3 ligase HECW1 catalyzes TTF1 ubiquitination.
      Title: The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system.
    6. Study reported for the first time that HECW1 mRNA levels were negatively correlated with Gd-IgA1 levels and pointed to a new regulatory mechanism of IgA nephropathy that can explain the aberrant glycosylation of IgA1.
      Title: Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy.
    7. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
      Title: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
    8. Ndel1 regulates Dyn2 GTPase activity and impacts GluR1-containing membranes distribution in a manner reminiscent of Dyn2.
      Title: The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity.
    9. These findings suggest that the human NEDL1 transgenic mice might develop Amyotrophic lateral sclerosis-like symptoms, showing signs of motor abnormalities, accompanied with significant reduction in muscle strength.
      Title: Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice.
    10. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis.
      Title: RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
    EBI GWAS Catalog
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0322

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase HECW1
    Names
    HECT type E3 ubiquitin ligase
    HECT-type E3 ubiquitin transferase HECW1
    NEDD4-like ubiquitin-protein ligase 1
    NP_001273988.1
    NP_055867.3
    XP_006715733.1
    XP_006715734.1
    XP_006715736.1
    XP_011513522.1
    XP_011513524.1
    XP_011513525.1
    XP_011513526.1
    XP_011513527.2
    XP_011513528.1
    XP_016867371.1
    XP_016867372.1
    XP_016867373.1
    XP_016867376.1
    XP_016867377.1
    XP_047276020.1
    XP_047276021.1
    XP_047276022.1
    XP_054213618.1
    XP_054213619.1
    XP_054213620.1
    XP_054213621.1
    XP_054213622.1
    XP_054213623.1
    XP_054213624.1
    XP_054213625.1
    XP_054213626.1
    XP_054213627.1
    XP_054213628.1
    XP_054213629.1
    XP_054213630.1
    XP_054213631.1
    XP_054213632.1
    XP_054213633.1
    XP_054213634.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287059.2 → NP_001273988.1  E3 ubiquitin-protein ligase HECW1 isoform b

      See identical proteins and their annotated locations for NP_001273988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC004692, AC011738, AK294918, BC151227
      Consensus CDS
      CCDS69286.1
      UniProtKB/Swiss-Prot
      Q76N89
      Related
      ENSP00000407774.1, ENST00000453890.5
      Conserved Domains (6) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:986 → 1017
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1240 → 1569
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:799 → 827
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    2. NM_015052.5 → NP_055867.3  E3 ubiquitin-protein ligase HECW1 isoform a

      See identical proteins and their annotated locations for NP_055867.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC011738, AK294918, BC151227
      Consensus CDS
      CCDS5469.2
      UniProtKB/Swiss-Prot
      A7E2X0, A8MYS3, B4DH42, O15036, Q76N89, Q9HCC7
      Related
      ENSP00000379228.1, ENST00000395891.7
      Conserved Domains (5) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:830 → 861
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1274 → 1603
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1250 → 1604
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      43112647..43566001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011883.3 → XP_016867372.1  E3 ubiquitin-protein ligase HECW1 isoform X1

    2. XM_006715670.4 → XP_006715733.1  E3 ubiquitin-protein ligase HECW1 isoform X3

      Conserved Domains (5) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:832 → 863
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1276 → 1605
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1252 → 1606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    3. XM_006715671.4 → XP_006715734.1  E3 ubiquitin-protein ligase HECW1 isoform X4

      Conserved Domains (5) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:831 → 862
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1275 → 1604
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1251 → 1605
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    4. XM_006715673.4 → XP_006715736.1  E3 ubiquitin-protein ligase HECW1 isoform X11

      Conserved Domains (6) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:987 → 1018
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1241 → 1570
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1217 → 1571
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:800 → 828
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    5. XM_017011882.2 → XP_016867371.1  E3 ubiquitin-protein ligase HECW1 isoform X1

    6. XM_017011887.2 → XP_016867376.1  E3 ubiquitin-protein ligase HECW1 isoform X7

    7. XM_017011884.2 → XP_016867373.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      Conserved Domains (5) summary
      cd08691
      Location:237 → 373
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:862 → 893
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1306 → 1635
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1282 → 1636
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:97 → 216
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    8. XM_017011888.2 → XP_016867377.1  E3 ubiquitin-protein ligase HECW1 isoform X8

    9. XM_047420064.1 → XP_047276020.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    10. XM_011515220.3 → XP_011513522.1  E3 ubiquitin-protein ligase HECW1 isoform X5

      See identical proteins and their annotated locations for XP_011513522.1

      Conserved Domains (5) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:831 → 862
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1275 → 1604
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1251 → 1605
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    11. XM_047420065.1 → XP_047276021.1  E3 ubiquitin-protein ligase HECW1 isoform X6

      UniProtKB/Swiss-Prot
      A7E2X0, A8MYS3, B4DH42, O15036, Q76N89, Q9HCC7

    12. XM_011515223.3 → XP_011513525.1  E3 ubiquitin-protein ligase HECW1 isoform X9

      See identical proteins and their annotated locations for XP_011513525.1

      Conserved Domains (5) summary
      cd08691
      Location:184 → 320
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:810 → 841
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1254 → 1583
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1230 → 1584
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:44 → 163
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    13. XM_047420066.1 → XP_047276022.1  E3 ubiquitin-protein ligase HECW1 isoform X10

      UniProtKB/TrEMBL
      A4D1V5

    14. XM_011515222.3 → XP_011513524.1  E3 ubiquitin-protein ligase HECW1 isoform X9

      See identical proteins and their annotated locations for XP_011513524.1

      Conserved Domains (5) summary
      cd08691
      Location:184 → 320
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:810 → 841
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1254 → 1583
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1230 → 1584
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:44 → 163
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    15. XM_011515224.3 → XP_011513526.1  E3 ubiquitin-protein ligase HECW1 isoform X9

      See identical proteins and their annotated locations for XP_011513526.1

      Conserved Domains (5) summary
      cd08691
      Location:184 → 320
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:810 → 841
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1254 → 1583
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1230 → 1584
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:44 → 163
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    16. XM_011515225.2 → XP_011513527.2  E3 ubiquitin-protein ligase HECW1 isoform X12

    17. XM_011515226.4 → XP_011513528.1  E3 ubiquitin-protein ligase HECW1 isoform X13

      Conserved Domains (4) summary
      cd08691
      Location:35 → 171
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:661 → 692
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1105 → 1434
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1081 → 1435
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      43270827..43724047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357643.1 → XP_054213618.1  E3 ubiquitin-protein ligase HECW1 isoform X1

    2. XM_054357645.1 → XP_054213620.1  E3 ubiquitin-protein ligase HECW1 isoform X3

    3. XM_054357646.1 → XP_054213621.1  E3 ubiquitin-protein ligase HECW1 isoform X4

    4. XM_054357657.1 → XP_054213632.1  E3 ubiquitin-protein ligase HECW1 isoform X11

    5. XM_054357650.1 → XP_054213625.1  E3 ubiquitin-protein ligase HECW1 isoform X7

    6. XM_054357651.1 → XP_054213626.1  E3 ubiquitin-protein ligase HECW1 isoform X8

    7. XM_054357644.1 → XP_054213619.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    8. XM_054357647.1 → XP_054213622.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    9. XM_054357648.1 → XP_054213623.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    10. XM_054357649.1 → XP_054213624.1  E3 ubiquitin-protein ligase HECW1 isoform X6

    11. XM_054357654.1 → XP_054213629.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    12. XM_054357656.1 → XP_054213631.1  E3 ubiquitin-protein ligase HECW1 isoform X10

    13. XM_054357652.1 → XP_054213627.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    14. XM_054357653.1 → XP_054213628.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    15. XM_054357655.1 → XP_054213630.1  E3 ubiquitin-protein ligase HECW1 isoform X9

    16. XM_054357658.1 → XP_054213633.1  E3 ubiquitin-protein ligase HECW1 isoform X12

    17. XM_054357659.1 → XP_054213634.1  E3 ubiquitin-protein ligase HECW1 isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76N89.3 GenPept UniProtKB/Swiss-Prot:Q76N89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous