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    ZNF287 zinc finger protein 287 [ Homo sapiens (human) ]

    Gene ID: 57336, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF287provided by HGNC
    Official Full Name
    zinc finger protein 287provided by HGNC
    Primary source
    HGNC:HGNC:13502
    See related
    Ensembl:ENSG00000141040 AllianceGenome:HGNC:13502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN45; ZKSCAN13
    Summary
    This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 1.8), thyroid (RPKM 1.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF287 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16546954..16569212, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16449237..16471499, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16450268..16472526, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903940 Neighboring gene uncharacterized LOC124903941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11768 Neighboring gene uncharacterized LOC105371554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16471581-16472082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16472083-16472582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11769 Neighboring gene zinc finger protein 624 Neighboring gene SRSF6 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:16556408-16556918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8228 Neighboring gene uncharacterized LOC124903934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma. Yang R, et al. Cancer Inform, 2014. PMID 25288879, Free PMC Article
    2. The biology of the mammalian Krüppel-like family of transcription factors. Dang DT, et al. Int J Biochem Cell Biol, 2000 Nov-Dec. PMID 11137451, Free PMC Article
    3. Zinc fingers: DNA binding and protein-protein interactions. Leon O, et al. Biol Res, 2000. PMID 11021307
    4. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Kim SO, et al. Int J Mol Sci, 2021 Jul 15. PMID 34299191, Free PMC Article
    5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126536, MGC141923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 287
    Names
    zinc finger protein with KRAB and SCAN domains 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051652.1 RefSeqGene

      Range
      5009..27259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346167.2 → NP_001333096.1  zinc finger protein 287 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Conserved Domains (5) summary
      smart00349
      Location:170 → 227
      KRAB; krueppel associated box
      COG5048
      Location:422 → 755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364 → 419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426 → 446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46 → 144
      SCAN; SCAN oligomerization domain

    2. NM_001346168.2 → NP_001333097.1  zinc finger protein 287 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Conserved Domains (5) summary
      smart00349
      Location:170 → 227
      KRAB; krueppel associated box
      COG5048
      Location:422 → 755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364 → 419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426 → 446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46 → 144
      SCAN; SCAN oligomerization domain

    3. NM_001346169.2 → NP_001333098.1  zinc finger protein 287 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Related
      ENSP00000379168.1, ENST00000395824.5
      Conserved Domains (5) summary
      smart00349
      Location:170 → 227
      KRAB; krueppel associated box
      COG5048
      Location:422 → 755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364 → 419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426 → 446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46 → 144
      SCAN; SCAN oligomerization domain

    4. NM_001346170.1 → NP_001333099.1  zinc finger protein 287 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC127540

    5. NM_001346171.2 → NP_001333100.1  zinc finger protein 287 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC127540

    6. NM_020653.4 → NP_065704.2  zinc finger protein 287 isoform a

      See identical proteins and their annotated locations for NP_065704.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC127540, BC057791, DA103127
      Consensus CDS
      CCDS11179.2
      UniProtKB/Swiss-Prot
      Q6IAG1, Q9HBT7
      Related
      ENSP00000379169.3, ENST00000395825.4
      Conserved Domains (5) summary
      smart00349
      Location:170 → 227
      KRAB; krueppel associated box
      COG5048
      Location:422 → 755
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:364 → 419
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:426 → 446
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:46 → 144
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      16546954..16569212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      16449237..16471499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBT7.2 GenPept UniProtKB/Swiss-Prot:Q9HBT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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