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    Slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 [ Mus musculus (house mouse) ]

    Gene ID: 239606, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc2a13provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 13provided by MGI
    Primary source
    MGI:MGI:2146030
    See related
    Ensembl:ENSMUSG00000036298 AllianceGenome:MGI:2146030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm308; 6530403A04; A630029G22Rik
    Summary
    Enables protease binding activity. Predicted to be involved in myo-inositol transport; positive regulation of amyloid-beta formation; and transmembrane transport. Located in organelle membrane. Is expressed in several structures, including brain; jaw; and thoracic segment skeleton. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 10.3), frontal lobe adult (RPKM 7.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc2a13 in Genome Data Viewer
    Location:
    15 E3; 15 46.05 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (91151894..91457467, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (91267691..91573261, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39495 Neighboring gene STARR-seq mESC enhancer starr_39496 Neighboring gene ATP-binding cassette, sub-family D member 2 Neighboring gene regulator of DNA class I crossover intermediates 1 Neighboring gene STARR-seq mESC enhancer starr_39497 Neighboring gene STARR-seq mESC enhancer starr_39498 Neighboring gene STARR-seq mESC enhancer starr_39499 Neighboring gene STARR-seq mESC enhancer starr_39500 Neighboring gene STARR-seq mESC enhancer starr_39501 Neighboring gene olfactomedin-like 2A pseudogene Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene STARR-seq mESC enhancer starr_39502 Neighboring gene STARR-positive B cell enhancer ABC_E8606 Neighboring gene STARR-positive B cell enhancer ABC_E4147 Neighboring gene leucine-rich repeat kinase 2 Neighboring gene STARR-seq mESC enhancer starr_39505 Neighboring gene RAS related protein 1b pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones. Uldry M, et al. EMBO J, 2004 Feb 11. PMID 14749729, Free PMC Article
    2. Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Fu H, et al. Neurochem Int, 2012 Jul. PMID 22564531
    3. Evaluation of expression and function of the H+/myo-inositol transporter HMIT. Di Daniel E, et al. BMC Cell Biol, 2009 Jul 16. PMID 19607714, Free PMC Article
    4. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. Teranishi Y, et al. FEBS J, 2015 Sep. PMID 26094765
    5. Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy. Kappen C, et al. Front Cell Dev Biol, 2022. PMID 35478964, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC2A13 is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch cleavage.
      Title: Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
    2. astrocytes obtained directly from the brain express HMIT and is expressed in neurons
      Title: Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH.
    3. Inositol transport and homeostasis were unaffected in H+/myo-inositol transporter targeted null-mutant mice.
      Title: Evaluation of expression and function of the H+/myo-inositol transporter HMIT.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myo-inositol transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myo-inositol:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myo-inositol:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myo-inositol:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in myo-inositol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myo-inositol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myo-inositol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in astrocyte end-foot IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in astrocyte end-foot ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proton myo-inositol cotransporter
    Names
    h(+)-myo-inositol cotransporter
    h(+)-myo-inositol symporter
    hmit
    solute carrier family 2 member 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033633.3 → NP_001028805.2  proton myo-inositol cotransporter

      See identical proteins and their annotated locations for NP_001028805.2

      Status: VALIDATED

      Source sequence(s)
      AK039571, AK147341, BB429800
      Consensus CDS
      CCDS27761.2
      UniProtKB/Swiss-Prot
      Q3UHK1
      UniProtKB/TrEMBL
      Q0VDP1
      Related
      ENSMUSP00000104906.2, ENSMUST00000109283.2
      Conserved Domains (2) summary
      cd06174
      Location:75 → 580
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:78 → 598
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      91151894..91457467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938837.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHK1.2 GenPept UniProtKB/Swiss-Prot:Q3UHK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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