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    Spag5 sperm associated antigen 5 [ Mus musculus (house mouse) ]

    Gene ID: 54141, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spag5provided by MGI
    Official Full Name
    sperm associated antigen 5provided by MGI
    Primary source
    MGI:MGI:1927470
    See related
    Ensembl:ENSMUSG00000002055 AllianceGenome:MGI:1927470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S17; MAP126; Deepest; Mastrin; D11Bhm180e
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within establishment of spindle orientation. Located in ciliary basal body; ciliary rootlet; and mitotic spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPAG5 (sperm associated antigen 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 16.1), testis adult (RPKM 15.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spag5 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78192412..78213283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78301470..78322457)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene predicted gene 3948 Neighboring gene ribosomal protein S6 kinase related Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene STARR-positive B cell enhancer ABC_E906 Neighboring gene aldolase C, fructose-bisphosphate Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of the testicular SPAG5/deepest protein does not affect spermatogenesis or fertility. Xue J, et al. Mol Cell Biol, 2002 Apr. PMID 11884588, Free PMC Article
    2. Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes. Yuan J, et al. Cell Cycle, 2009 Oct 15. PMID 19806032
    3. SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice. Guo L, et al. BMC Cardiovasc Disord, 2024 May 28. PMID 38807081, Free PMC Article
    4. Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein. Mack GJ, et al. Proc Natl Acad Sci U S A, 2001 Dec 4. PMID 11724960, Free PMC Article
    5. Expression and promoter analysis of mouse mastrin gene. Chang MS, et al. Biochem Biophys Res Commun, 2003 Aug 1. PMID 12893248

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE[-/-] mice.
      Title: SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
    2. Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
      Title: Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes.
    3. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
      Title: Expression and promoter analysis of mouse mastrin gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within establishment of spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of attachment of spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of metaphase plate congression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sperm-associated antigen 5
    Names
    astrin
    microtubule-associated protein
    mitotic spindle-associated protein p126

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017407.3 → NP_059103.1  sperm-associated antigen 5

      See identical proteins and their annotated locations for NP_059103.1

      Status: VALIDATED

      Source sequence(s)
      AL591070
      Consensus CDS
      CCDS25098.1
      UniProtKB/Swiss-Prot
      B1AQC8, Q7TME2, Q8CH61
      Related
      ENSMUSP00000045286.4, ENSMUST00000045026.4
      Conserved Domains (1) summary
      COG1196
      Location:524 → 1144
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. NR_156178.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591070

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78192412..78213283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156853.1 → XP_036012746.1  sperm-associated antigen 5 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:1 → 568
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:58 → 313
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_001780027.2 RNA Sequence

    2. XR_001780026.2 RNA Sequence

    3. XR_004936991.1 RNA Sequence

    4. XR_004936992.1 RNA Sequence

    5. XR_003949480.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TME2.1 GenPept UniProtKB/Swiss-Prot:Q7TME2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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