GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE87610 Query DataSets for GSE87610
Status Public on Apr 04, 2017
Title Gene expression of L3 and L5 pyramidal neurons in the DLPFC comparing schizophrenia from bipolar major depressive disorders and unaffected subjects.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder (BP) and least in major depressive disorder (MDD).
Given that working memory depends, in part, on neural circuitry that includes pyramidal neurons in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis.
Overall design We collected brain specimens (n=76) with SZ (n=19; 6 had schizoaffective disorder), BP (n=19; all had bipolar 1 disorder) or MDD (n=19) and UC subjects (n=19) which were matched as tetrads for sex and as closely as possible for age. Each subject has 2 technique replicates.
Contributor(s) Arion D, Enwright JF, Corradi JP, Huo Z, Tseng G, Lewis DA
Citation(s) 28476208, 33328902
Submission date Oct 04, 2016
Last update date Dec 22, 2020
Contact name David Lewis
Organization name University of Pittsburgh
Department Psychiatry and Neuroscience
Street address 3811 O'Hara St
City Pittsburgh
State/province PA
ZIP/Postal code 15213
Country USA
Platforms (1)
GPL13667 [HG-U219] Affymetrix Human Genome U219 Array
Samples (286)
GSM2335074 20-BP-L3-1
GSM2335075 20-BP-L3-2
GSM2335076 20-BP-L5-3
BioProject PRJNA345378

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE87610_RAW.tar 966.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap