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| Status |
Public on Apr 04, 2017 |
| Title |
Gene expression of L3 and L5 pyramidal neurons in the DLPFC comparing schizophrenia from bipolar major depressive disorders and unaffected subjects. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder (BP) and least in major depressive disorder (MDD).
Given that working memory depends, in part, on neural circuitry that includes pyramidal neurons in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis.
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| Overall design |
We collected brain specimens (n=76) with SZ (n=19; 6 had schizoaffective disorder), BP (n=19; all had bipolar 1 disorder) or MDD (n=19) and UC subjects (n=19) which were matched as tetrads for sex and as closely as possible for age. Each subject has 2 technique replicates.
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| Contributor(s) |
Arion D, Enwright JF, Corradi JP, Huo Z, Tseng G, Lewis DA |
| Citation(s) |
28476208, 33328902 |
| |
| Submission date |
Oct 04, 2016 |
| Last update date |
Dec 22, 2020 |
| Contact name |
David Lewis |
| E-mail(s) |
lewisda@upmc.edu
|
| Organization name |
University of Pittsburgh
|
| Department |
Psychiatry and Neuroscience
|
| Street address |
3811 O'Hara St
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
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| Platforms (1) |
| GPL13667 |
[HG-U219] Affymetrix Human Genome U219 Array |
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| Samples (286)
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| Relations |
| BioProject |
PRJNA345378 |
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