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| Status |
Public on Feb 08, 2017 |
| Title |
Mistimed sleep disrupts circadian regulation of the human blood transcriptome - Heterozygotes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
4 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake cycle and the associated fasting-feeding cycle is scheduled to a 28-hour period, of which one third (i.e. 9h 20min) is scheduled for sleep. Under these conditions, during which light levels in the waking episode are kept low and sleep is scheduled in darkness, the phase of the melatonin rhythm occurred at approximately the same clock time during the first (D1) and fourth (D4) 28-h cycle and there were no major changes in either the amplitude or the waveform of this rhythm. During D1 and D4 7 blood samples were taken, RNA was extracted from leukocytes, labelled and hybridised to human whole-genome microarrays
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| Overall design |
A total of 23 samples comprising 4 human subjects, for which 14 samples across multiple time-points/sleep condition were collected.
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| Contributor(s) |
Moller-Levet C, Archer S, Bucca G, Laing E, Slak A, Kabiljo R, Lo J, Santhi N, von Schantz M, Smith CP, Dijk DJ |
| Citation(s) |
28218891 |
| Submission date |
Jun 01, 2016 |
| Last update date |
May 11, 2017 |
| Contact name |
Emma Laing |
| E-mail(s) |
e.laing@surrey.ac.uk
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| Organization name |
University of Surrey
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| Street address |
Stag Hill
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| City |
Guildford |
| ZIP/Postal code |
GU22 7XH |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL15331 |
Agilent-026817 University_Surrey_HumanSleep_44k_v1 |
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| Samples (23)
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| GSM2183625 |
BloodAtTimepoint5,followingSleepInPhaseWithMelatoninForSubjectBB0008 |
| GSM2183626 |
BloodAtTimepoint6,followingSleepInPhaseWithMelatoninForSubjectBB0008 |
| GSM2183627 |
BloodAtTimepoint7,followingSleepInPhaseWithMelatoninForSubjectBB0008 |
| GSM2183628 |
BloodAtTimepoint1,followingSleepOutOfPhaseWithMelatoninForSubjectBB0008 |
| GSM2183629 |
BloodAtTimepoint3,followingSleepOutOfPhaseWithMelatoninForSubjectBB0008 |
| GSM2183630 |
BloodAtTimepoint4,followingSleepOutOfPhaseWithMelatoninForSubjectBB0008 |
| GSM2183631 |
BloodAtTimepoint5,followingSleepInPhaseWithMelatoninForSubjectBB0065 |
| GSM2183632 |
BloodAtTimepoint6,followingSleepInPhaseWithMelatoninForSubjectBB0065 |
| GSM2183633 |
BloodAtTimepoint7,followingSleepInPhaseWithMelatoninForSubjectBB0065 |
| GSM2183634 |
BloodAtTimepoint1,followingSleepOutOfPhaseWithMelatoninForSubjectBB0065 |
| GSM2183635 |
BloodAtTimepoint3,followingSleepOutOfPhaseWithMelatoninForSubjectBB0065 |
| GSM2183636 |
BloodAtTimepoint4,followingSleepOutOfPhaseWithMelatoninForSubjectBB0065 |
| GSM2183637 |
BloodAtTimepoint5,followingSleepInPhaseWithMelatoninForSubjectBB0081 |
| GSM2183638 |
BloodAtTimepoint7,followingSleepInPhaseWithMelatoninForSubjectBB0081 |
| GSM2183639 |
BloodAtTimepoint1,followingSleepOutOfPhaseWithMelatoninForSubjectBB0081 |
| GSM2183640 |
BloodAtTimepoint3,followingSleepOutOfPhaseWithMelatoninForSubjectBB0081 |
| GSM2183641 |
BloodAtTimepoint4,followingSleepOutOfPhaseWithMelatoninForSubjectBB0081 |
| GSM2183642 |
BloodAtTimepoint5,followingSleepInPhaseWithMelatoninForSubjectBB0214 |
| GSM2183643 |
BloodAtTimepoint6,followingSleepInPhaseWithMelatoninForSubjectBB0214 |
| GSM2183644 |
BloodAtTimepoint7,followingSleepInPhaseWithMelatoninForSubjectBB0214 |
| GSM2183645 |
BloodAtTimepoint1,followingSleepOutOfPhaseWithMelatoninForSubjectBB0214 |
| GSM2183646 |
BloodAtTimepoint3,followingSleepOutOfPhaseWithMelatoninForSubjectBB0214 |
| GSM2183647 |
BloodAtTimepoint4,followingSleepOutOfPhaseWithMelatoninForSubjectBB0214 |
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| Relations |
| BioProject |
PRJNA324077 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE82113_RAW.tar |
48.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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