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Series GSE60190 Query DataSets for GSE60190
Status Public on Aug 08, 2014
Title Genetic Neuropathology of Obsessive Psychiatric Syndromes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Anorexia nervosa (AN), bulimia nervosa (BN), and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought to arise from the interaction of multiple genes of small effect with environmental factors. Potential candidate genes for AN, BN, and OCD have been identified through clinical association and neuroimaging studies; however, recent genome-wide association studies of eating disorders (ED) so far have failed to report significant findings. Additionally, few if any studies have interrogated postmortem brain tissue for evidence of eQTLs associated with candidate genes, which has particular promise as an approach to elucidating molecular mechanisms of association. We therefore selected single nucleotide polymorphisms (SNPs) based on candidate gene studies for AN, BN, and OCD from the literature, and examined the association of these SNPs with gene expression across the lifespan in prefrontal cortex of a non-psychiatric control cohort (N=268). Several risk-predisposing SNPs were significantly associated with gene expression among control subjects. We then measured gene expression in the prefrontal cortex of cases previously diagnosed with obsessive psychiatric disorders, e.g., eating disorders (ED; N=15), and obsessive-compulsive disorder/obsessive-compulsive personality disorder or tics (OCD/OCPD/Tic; N=16), and non-psychiatric controls (N=102) and identified 6 and 286 genes that were differentially expressed between ED compared to controls and OCD cases compared to controls, respectively (FDR < 5%). However, none of the clinical risk SNPs were among the eQTLs and none were significantly associated with gene expression within the broad obsessive cohort, suggesting larger sample sizes or other brain regions may be required to identify candidate molecular mechanisms of clinical association in postmortem brain datasets.
Overall design Gene expression data from the dorsolateral prefrontal cortex (DLPFC) from postmortem tissue on 133 subjects - 15 eating disorder (ED) patients, 16 obessive compulsive disorder (OCD) patients, and 102 non-psychiatric controls - run on the Illumina HumanHT-12 v3 microarray
Contributor(s) Jaffe AE
Citation(s) 25180571
Submission date Aug 07, 2014
Last update date Aug 16, 2018
Contact name Andrew Jaffe
Phone 1-443-287-6864
Organization name Lieber Institute for Brain Development
Department Clinical Sciences
Street address 855 N Wolfe St, Ste 300
City Baltimore
State/province MD
ZIP/Postal code 21205
Country USA
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (133)
GSM1467273 DLPFC_ED_1
GSM1467274 DLPFC_Control_1
GSM1467275 DLPFC_OCD_1
BioProject PRJNA257722

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60190_RAW.tar 6.2 Mb (http)(custom) TAR
GSE60190_non-normalized.txt.gz 25.9 Mb (ftp)(http) TXT
Processed data included within Sample table

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