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Status |
Public on Jan 21, 2014 |
Title |
Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by high throughput sequencing
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Summary |
Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depressive disorder also show increased global variation in methylation in comparison with their unaffected co-twins. ZBTB20 plays an essential role in the specification of the Cornu Ammonis-1 field identity in the developing hippocampus, a region previously implicated in the development of major depressive disorder.
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Overall design |
Epigenetic study of MZ twins discordant for Major Depressive Disorder
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Contributor(s) |
Bell JT, Davies MN |
Citation missing |
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Submission date |
Jan 20, 2014 |
Last update date |
May 15, 2019 |
Contact name |
Matthew N Davies |
Organization name |
King's College London
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Department |
Twin Research
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Lab |
Twin Research
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Street address |
St Thomas' Hospital Campus
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City |
London |
State/province |
Greater London |
ZIP/Postal code |
SE1 7EH |
Country |
United Kingdom |
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Platforms (1) |
GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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Samples (54)
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Relations |
BioProject |
PRJNA235960 |
SRA |
SRP035541 |