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Series GSE44593 Query DataSets for GSE44593
Status Public on Jan 01, 2016
Title Molecular Evidence for a Dimensional Basis of Depression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Here we identified a set of genes with frequent expression changes in the postmortem brain of MDD subjectsand show that this gene set is genetically related to brain and organ illnesses frequently associated with MDD. Specifically, we performed a meta-analysis of eight gene array studies in three corticolimbic brain regions and identified ~450 genes frequentlyderegulated in MDD (n=103 subjects, 50.5%MDD). These “MetaA-MDD” genes includepreviously-implicated neuroplasticity- and stress-related genes (CRH, BDNF, VGF), encompass multiple synaptic and signaling pathways, and suggests complex changes in cell structure and function. MetaA-MDD genes display low connectivity andhubnessin coexpression networks andare evenly distributed throughout the genome. However, MetaA-MDD genesare significantly over-represented in gene sets identified by the genome-wide association studies for brain disorders and organ diseases sharing clinical co-morbidity with MDD (e.g., cardiovascular, metabolic syndrome), but not for other diseases or body functions. Together, this study describes a robustmolecular characterization of altered brain function in MDD, and provides evidence for a shared genetic structure linking MDD andrelated illnesses, together biologically defining abroader dimensional definition ofa depressive-like syndrome.
Overall design 14 pairs of human postmotem AMY samples of MDD patients and control
Contributor(s) Sibille E
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Submission date Feb 22, 2013
Last update date Mar 25, 2019
Contact name YING DING
Organization name Pfizer
Department Computational Biology
Street address 10777 Science Center Dr.
City San Diego
State/province CA
ZIP/Postal code 92121
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (28)
GSM1087510 Control 795
GSM1087511 Control 615
GSM1087512 Control 713
BioProject PRJNA190603

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Supplementary file Size Download File type/resource
GSE44593_RAW.tar 138.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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