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Series GSE24095 Query DataSets for GSE24095
Status Public on Oct 17, 2010
Title Human postmortem hippocampus: Major depressive disorder (MDD) vs. Control
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We examined the genetic profile of postmortem brain (hippocampal) samples; 15 brains from patients diagnosed with MDD were matched to brains from healthy subjects based on gender, race and age. Gene expression profiles in the dentate gyrus and CA1 subregions of the hippocampus were assessed by cDNA hybridization to 48K human HEEBO whole genome microarrays (Microarray, Inc).
Overall design Two-group comparison: MDD (13 male, 8 female) vs. Control (11 male, 7 female). Dentate Gyrus (DG): 15 pairs of samples (1 array per pair); CA1: 15 pairs of samples (1 array per pair). Biological replicates.
We can not provide a list of normalized values for each individual hybridization (per chip), but rather have a list of average expression values for all hybridizations used in the experiment (n=15). See supplementary files below.

AAm, African American; C, Caucasian; CO, carbon monoxide; CVD, cardiovascular disease; ETOH, ethanol; F, female; Hx, history of alcohol abuse but not currently active; M, male; MDD, Major Depressive disorder, ND, no psychotropic medication detected; NOS, not otherwise specified, OD, drug overdose; PE, prior episode of major depression with psychotic features; PMI, postmortem interval (hours); SIGSW, self-inflicted gunshot wound; [1], Psychotrophic prescriptions within last month; [2], MDD in remission; [3], prescriptions for six days prior to death; *, samples present only in array sets for the dentate gyrus; **, samples present only in array sets for CA1.
Contributor(s) Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS
Citation(s) 20953200, 22339950
Submission date Sep 13, 2010
Last update date Sep 10, 2014
Contact name Vanja Duric
Organization name Yale University
Street address 34 Park Street
City New Haven
State/province CT
ZIP/Postal code 06508
Country USA
Platforms (1)
GPL10907 Microarrays Inc. Human Genomic 49K MI Ready Array [HEEBO]
Samples (30)
GSM593079 DG_3B (MDD) vs. 3D (Control)
GSM593080 DG_4B (MDD) vs. 4D (Control)
GSM593081 DG_5B (MDD) vs. 23D (Control)
BioProject PRJNA130293

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24095_CA1_normalized_data_AVG.txt.gz 1.3 Mb (ftp)(http) TXT
GSE24095_DG_normalized_data_AVG.txt.gz 1.1 Mb (ftp)(http) TXT
GSE24095_RAW.tar 164.0 Mb (http)(custom) TAR (of GPR)
Processed data are available on Series record

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