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Series GSE12654 Query DataSets for GSE12654
Status Public on Sep 04, 2008
Title Gene expression from human prefrontal cortex (BA10)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. Notably, most of the altered gene expressions in each disease were not shared by one another, suggesting the molecular distinctiveness of these mental disorders. We found a tendency of downregulation of the genes encoding receptor, channels or transporters, and upregulation of the genes encoding stress response proteins or molecular chaperons in bipolar disorder. Altered expressions in bipolar disorder shared by other mental disorders mainly consisted of upregulation of the genes encoding proteins for transcription or translation. The genes identified in this study would be useful for the understanding of the pathophysiology of bipolar disorder, as well as the common pathophysiological background in major mental disorders at the molecular level.
Keywords: disease state analysis
Overall design A total of 50 postmortem brains obtained from the Stanley Medical Research Institute were used for DNA microarray analysis. Fresh frozen samples were used for RNA extraction.
Contributor(s) Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T
Citation(s) 14743183
Submission date Sep 03, 2008
Last update date Dec 13, 2018
Contact name Kazuya Iwamoto
Phone +81-48-467-6949
Fax +81-48-467-6947
Organization name RIKEN
Department Brain Science Institute
Lab Lab for Molecular Dynamics of Mental Disorders
Street address 2-1 Hirosawa
City Wako
ZIP/Postal code 351-0198
Country Japan
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (50)
GSM317649 control, BA10-1
GSM317650 depression, BA10-2
GSM317651 depression, BA10-3
BioProject PRJNA113059

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12654_RAW.tar 135.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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