GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE120062 Query DataSets for GSE120062
Status Public on Sep 24, 2018
Title DNA Methylation data from frozen placental tissue
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Maternal obesity alters placental tissue function and morphology with a corresponding increase in local inflammation.
We and others showed that placenta size, inflammation and fetal growth are regulated by maternal diet and obesity status. Maternal obesity alters placental DNA methylation which in turn could likely impact gene transcription of
of proteins critical for normal fetal development. RNA-binding motif single-stranded interacting protein 1 (RBMS1) is expressed by the placenta and likely modulates DNA replication and transcription regulation.
Serum RBMS1 protein concentration is increased with maternal obesity and RBMS1 gene expression in liver tissue is induced by a high-fat diet and inflammation. However, it is not yet known whether placental RBMS1 mRNA expression and DNA methylation are altered by maternal obesity.
Overall design Methylation profiles of frozen placental tissue samples from overweight/obese (BMI>25) and non-overweight (BMI<25) were anaylzed
Contributor(s) Claycombe K, Dhasarathy A, Bundy AN, Bhattacharya A, Darland D, Hur J, Perley D, Johnson L, Roemmich JN
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Sep 17, 2018
Last update date Mar 22, 2019
Contact name Kate J Claycombe-Larson
Phone 701-795-8298
Organization name USDA
Department ARS
Lab Nutritional Immunology and Epigenetics
Street address 2420 2nd Avenue North
City Grand Forks
State/province ND
ZIP/Postal code 58203
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (38)
GSM3392710 Placental-Lean-BioRep1-TechRep1
GSM3392711 Placental-Lean-BioRep2-TechRep1
GSM3392712 Placental-Lean-BioRep2-TechRep2
BioProject PRJNA491492

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE120062_Matrix_Signal_Intensity.txt.gz 75.0 Mb (ftp)(http) TXT
GSE120062_RAW.tar 498.2 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap