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Series GSE114852 Query DataSets for GSE114852
Status Public on May 25, 2018
Title Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Prenatal exposure to maternal stress and depression has been identified as a risk factor for adverse behavioral and neurodevelopmental outcomes in early childhood. However, the molecular mechanisms through which maternal psychopathology shapes offspring development remain poorly understood. We analyzed transcriptome-wide gene expression profiles of 149 UCB samples from neonates born to mothers with prenatal PTSD (n=20), depression (n=31) and PTSD with comorbid depression (PTSD/Dep; n=13), compared to neonates born to carefully matched trauma exposed controls without meeting PTSD criteria (TE; n=23) and healthy mothers (n=62). We also evaluated physiological and developmental measures in these infants at birth, six months and twenty-four months. A multistep analytic approach was used that specifically sought to: 1) identify dysregulated genes, molecular pathways and discrete groups of co-regulated gene modules in UCB associated with prenatal maternal psychopathologies; and 2) to determine the impact of perinatal PTSD and depression on early childhood development outcomes.
 
Overall design Transcriptome-wide gene expression assays were applied to umbilical cord blood samples from neonates born to mothers with posttraumatic stress disorder (PTSD; n=20), depression (n=31) and PTSD with comorbid depression (n=13) compared to carefully matched trauma exposed controls (n=23) and healthy mothers (n=62).
 
Contributor(s) Breen MS
Citation(s) 29791872
Submission date May 24, 2018
Last update date Aug 13, 2018
Contact name Michael S Breen
Organization name Ichan School of Medicine at Mount Sinai
Department Depts. of Psychiatry, Genetics and Genomic Sciences
Street address 1468 Madison Ave
City New York
State/province NY
ZIP/Postal code 10029
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (149)
GSM3151687 Sample1: Umbilical cord blood - Depression
GSM3151688 Sample2: Umbilical cord blood - Depression
GSM3151689 Sample3: Umbilical cord blood - Depression
Relations
BioProject PRJNA472864

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE114852_NormExprs.txt.gz 7.7 Mb (ftp)(http) TXT
GSE114852_RAW.tar 26.2 Mb (http)(custom) TAR
GSE114852_RawExprs.txt.gz 35.2 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record
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