GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE99824 Query DataSets for GSE99824
Status Public on Jul 12, 2017
Title Molecular pathogenesis of human prostate basal cell hyperplasia reveals a keratinocyte metaplasia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The incidence of basal cell hyperplasia (BCH) has been reported at 8-10%, but a molecular and cellular characterization has not been performed on this phenotype. Using freshly digested tissue from surgical specimens, we performed transcriptomic analysis of flow cytometry-purified basal epithelia from patients with and without a majority BCH phenotype. Gene set enrichment analysis revealed an increased expression of members of the epidermal differentiation complex, resembling the progression of other metaplastic diseases.
Overall design In order to generate a clean molecular profile of BCH, free of contaminating signal from leukocytes, stroma and luminal epithelia, we performed RNA sequencing on bulk-isolated basal epithelia from 3 patients with basal hyperplasia and 4 patients without BCH
Contributor(s) Strand DW, Henry GH
Citation(s) 28795417
NIH grant(s)
Grant ID Grant title Affiliation Name
K01 DK098277 Mechanisms of Fatty Acid Metabolism in Prostate Differentiation and Disease UT SOUTHWESTERN MEDICAL CENTER Douglas William Strand
R03 DK110497 Interplay Between Stem Cells and Inflammation in Benign Prostatic Hyperplasia UT SOUTHWESTERN MEDICAL CENTER Douglas William Strand
Submission date Jun 08, 2017
Last update date May 15, 2019
Contact name Gervaise H. Henry
Phone 2146480497
Organization name UT Southwestern Medical Center
Department Urology
Lab Strand Lab
Street address 5323 Harry Hines Blvd, Mail Code:9110
City Dallas
State/province Texas
ZIP/Postal code 75390
Country USA
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (7)
GSM2653786 BPH132INBE
GSM2653787 BPH117BE
GSM2653788 BPH110BE
BioProject PRJNA389735
SRA SRP108858

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE99824_genes.fpkm_table.txt.gz 1007.3 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap