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Series GSE995 Query DataSets for GSE995
Status Public on Jan 30, 2004
Title Differentiation of acute myeloid leukemia cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute myeloid leukemia cells. In screening 1,739 compounds, we identified 8 that reliably induced the differentiation signature, and furthermore yielded functional evidence of bona fide differentiation.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series
Web link
Contributor(s) Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR
Citation(s) 14770183
Submission date Jan 26, 2004
Last update date Aug 10, 2018
Contact name Ken Ross
Phone 617-714-7473
Fax 617-714-8955
Organization name Broad Institute
Department Cancer Genomics
Lab Golub Lab
Street address 7 Cambridge Center
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
Platforms (2)
GPL80 [Hu6800] Affymetrix Human Full Length HuGeneFL Array
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (117)
GSM15272 APL1
GSM15394 APL2
GSM15395 APL_RA1
This SuperSeries is composed of the following SubSeries:
GSE976 Gene Expression-Based High Throughput Screening: APL Treatment with Candidate Compounds
GSE982 Gene Expression-Based High Throughput Screening: HL-60 Cell Treatment with Candidate Compounds
GSE983 Gene Expression-Based High Throughput Screening: Primary Patient AML Blasts, Normal Neutrophils, and Normal Monocytes
BioProject PRJNA88047

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE995_RAW.tar 361.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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