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Series GSE98381 Query DataSets for GSE98381
Status Public on Aug 22, 2017
Title Genome-wide chromatin conformation capture (Hi-C) analysis in fission yeast.
Organism Schizosaccharomyces pombe
Experiment type Other
Summary The dynamic nature of genome organization impacts critical nuclear functions including the regulation of gene expression, replication and DNA damage repair. Despite significant progress, the mechanisms responsible for reorganization of the genome in response to cellular stress, such as aberrant DNA replication, are poorly understood. Here we show that fission yeast cells carrying a mutation in the DNA binding protein Sap1 show defects in DNA replication progression and genome stability, and display extensive changes in genome organization.
Overall design Two biological replicates of Hi-C experiments were done in sap1-1.
Contributor(s) Mizuguchi T, Taneja N, Matsuda E, Belton J, FitzGerald P, Dekker J, Grewal SS
Citation(s) 28490498
Submission date May 01, 2017
Last update date May 15, 2019
Contact name Shiv Grewal
Phone 2407607553
Organization name NCI
Department LBMB
Lab Shiv Grewal
Street address NCI bldg 37 Rm 6068 9000 Rockville Pike
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL13988 Illumina HiSeq 2000 (Schizosaccharomyces pombe)
Samples (2)
GSM2592991 Hi-C in sap1-1mutant R1
GSM2592992 Hi-C in sap1-1mutant R2
This SubSeries is part of SuperSeries:
GSE96883 Shelterin Mediates Genome Reorganization in Response to Replication Stress
BioProject PRJNA384955
SRA SRP105763

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE98381_pombeHiC-188.matrix.gz 3.9 Mb (ftp)(http) MATRIX
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