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Series GSE9807 Query DataSets for GSE9807
Status Public on Feb 01, 2009
Title Expression data from RNAi SNCA treated human neuroblastoma cell line
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The pre-synaptic protein α-synuclein is a key player in the pathogenesis of Parkinson's disease. Together with accumulation and missfolding of α-synuclein protofibrils serve as seed structures for the aggregation of numerous proteins in the cytoplasm of neuronal cells, the so-called Lewy bodies. Furthermore, missense mutations in the SNCA gene and gene multiplications lead to autosomal dominant forms of familiar PD. However, so far the exact biological role of α-synuclein in normal brain is elusive. To gain more insights into the biological function of this protein we monitored whole genome expression changes in dopaminergic neuroblastoma cells (SH-SY5Y) caused by a 90% reduction of α-synuclein by RNA interference.
Keywords: whole genome expression changes through the loss of α-synuclein
 
Overall design comparison of expression profil changes in cells with normal α-synuclein level (control siRNA treatment) and reduced α-synuclein level (siSNCA4 treatment), triplicatesof each condition
 
Contributor(s) Bonin M, Häbig K
Citation(s) 19135032
Submission date Dec 06, 2007
Last update date Mar 25, 2019
Contact name Karina Haebig
E-mail(s) karina.haebig@med.uni-tuebingen.de
Organization name Institute of Human Genetics
Department Medical Genetics
Lab Microarray Facility
Street address Calwerstr. 7
City Tuebingen
ZIP/Postal code 72076
Country Germany
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (6)
GSM247508 Expression data from RNAi SNCA treated human neuroblastoma cell line
GSM247513 Expression data from RNAi SNCA treated human neuroblastoma cell line_si control_Repl2
GSM247514 Expression data from RNAi SNCA treated human neuroblastoma cell line_transfected with control siRNA_Replicate 3
Relations
BioProject PRJNA103753

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Supplementary file Size Download File type/resource
GSE9807_RAW.tar 26.6 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table

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