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Series GSE97154 Query DataSets for GSE97154
Status Public on Mar 30, 2017
Title MicroRNAs 146a/b-5p, 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Background: Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only about 30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and eight weeks after treatment.
Results: Our results revealed differential expression of miR-146a-5p, miR-146b-5p, miR-425-3p and miR-24-3p according to treatment response. These results were replicated in two independent clinical trials of MDD, a well-characterized animal model of depression, and post-mortem human brains. Furthermore, using a combination of bioinformatics, mRNA studies and functional in vitro experiments, we showed significant dysregulation of genes involved in MAPK/Wnt signaling pathways.
Conclusions: Together, our results indicate that these miRNAs are consistent markers of treatment response and regulators of the MAPK/Wnt systems.
 
Overall design MicroRNAs as biomarkers of antidepressant response
 
Contributor(s) Lopez JP, Turecki G, Théroux J
Citation(s) 28530238
Submission date Mar 28, 2017
Last update date May 15, 2019
Contact name Juan Pablo Lopez
E-mail(s) juan.lopez@mail.mcgill.ca
Phone 514 7616131
Organization name McGill University
Department Human Genetics
Lab McGill Group for Suicide Studies (MGSS)
Street address 6875 La Salle Blvd
City Montreal
State/province Quebec
ZIP/Postal code H4H1R3
Country Canada
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (516)
GSM2552328 T0.D.2670001
GSM2552329 T8.D.2670001
GSM2552330 T0.P.2670004
Relations
BioProject PRJNA380819
SRA SRP102680

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Supplementary file Size Download File type/resource
GSE97154_dcrt_processed_normalized_data_file.txt.gz 634.6 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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