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Series GSE97154 Query DataSets for GSE97154
Status Public on Mar 30, 2017
Title MicroRNAs 146a/b-5p, 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Background: Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only about 30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and eight weeks after treatment.
Results: Our results revealed differential expression of miR-146a-5p, miR-146b-5p, miR-425-3p and miR-24-3p according to treatment response. These results were replicated in two independent clinical trials of MDD, a well-characterized animal model of depression, and post-mortem human brains. Furthermore, using a combination of bioinformatics, mRNA studies and functional in vitro experiments, we showed significant dysregulation of genes involved in MAPK/Wnt signaling pathways.
Conclusions: Together, our results indicate that these miRNAs are consistent markers of treatment response and regulators of the MAPK/Wnt systems.
Overall design MicroRNAs as biomarkers of antidepressant response
Contributor(s) Lopez JP, Turecki G, Théroux J
Citation(s) 28530238
Submission date Mar 28, 2017
Last update date May 15, 2019
Contact name Juan Pablo Lopez
Phone 514 7616131
Organization name McGill University
Department Human Genetics
Lab McGill Group for Suicide Studies (MGSS)
Street address 6875 La Salle Blvd
City Montreal
State/province Quebec
ZIP/Postal code H4H1R3
Country Canada
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (516)
GSM2552328 T0.D.2670001
GSM2552329 T8.D.2670001
GSM2552330 T0.P.2670004
BioProject PRJNA380819
SRA SRP102680

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Supplementary file Size Download File type/resource
GSE97154_dcrt_processed_normalized_data_file.txt.gz 634.6 Kb (ftp)(http) TXT
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Raw data are available in SRA
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