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Series GSE96914 Query DataSets for GSE96914
Status Public on Sep 11, 2017
Title Autocrine BMP-4 signaling promotes survival of colorectal cancer cells.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Prognoses are poor for colorectal cancer (CRC) patients with metastatic lesions, leading to high demand for the development of novel molecular target therapies. Here, we demonstrate that expression of bone morphogenetic protein 4 (BMP4) is universally up-regulated and endogenous BMP signaling is activated in human CRC cells and tissues. Inhibition of endogenous BMP signaling by the BMP type I receptor inhibitor LDN-193189 led to elevated expression of dual specificity phosphatase 5 (DUSP5) in CRC cells, inducing apoptosis through the dephosphorylation of Erk MAP kinase. Administration of LDN-193189 to mice diminished tumor formation of CRC cells in vivo. Our findings thus suggest that inhibition of autocrine BMP-4 by BMP inhibitors represents a promising candidate method for treatment of CRC.
Overall design Target genes for BMPs in CRC cells were identified using LDN-193189.
Contributor(s) Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K, Ehata S
Citation(s) 28611046
Submission date Mar 22, 2017
Last update date May 15, 2019
Contact name Shogo Ehata
Organization name The University of Tokyo
Department Graduate School of Medicine
Lab Deaprtment of Molecular Pathology
Street address Hongo 7-3-1, Bunkyo-ku
City Tokyo
ZIP/Postal code 113-0033
Country Japan
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (4)
GSM2545824 RNA-seq_HT29_DMSO
GSM2545825 RNA-seq_HT29_LDN-193189
GSM2545826 RNA-seq_DLD-1_DMSO
BioProject PRJNA380084
SRA SRP102291

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Supplementary file Size Download File type/resource
GSE96914_DLD-1.xlsx 13.8 Mb (ftp)(http) XLSX
GSE96914_HT29.xlsx 13.0 Mb (ftp)(http) XLSX
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