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| Status |
Public on Mar 14, 2017 |
| Title |
Expression data that were specifically regulated by lncRNA-LFAR1 in mouse primary HSCs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Long noncoding RNAs (lncRNAs) play important roles in various biological processes; however, few have been identified that regulate hepatic stellate cells (HSCs) activation and the progression of liver fibrosis. Through a detailed analysis of the expression of lncRNAs in various tissues, we discovered the existence of a liver enriched lncRNA-LFAR1 (lncRNA-Liver Fibrosis Associated RNA1). To identify the roles of lncRNA-LFAR1 in liver fiboris, we systematically analyzed the regulation of mRNAs in primary HSCs infected with two separated lnc-LFAR1-shRNAs by RNA-seq, which revealed a panel of mRNAs that were specifically regulated by lncRNA-LFAR1 in mouse primary HSCs.
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| Overall design |
To identify the roles of lncRNA-LFAR1 in liver fibrosis, we systematically analyzed the regulation of mRNAs in primary HSCs infected with shRNA-control (n=2), lncRNA-shRNA1 (n=2) and lncRNA-shRNA3 (n=2) by RNA-seq.
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| Contributor(s) |
Hong W, Han T, Zhang K |
| Citation(s) |
28747678 |
| |
| Submission date |
Mar 13, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Kun Zhang |
| E-mail(s) |
zhangkun@tmu.edu.cn
|
| Phone |
022-83336819
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| Organization name |
Tianjin medical university
|
| Department |
Department of Histology and Embryology
|
| Street address |
Qixiangtai Road NO.22
|
| City |
Tianjin |
| ZIP/Postal code |
300070 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| GSM2534811 |
primary HSCs infected with shRNA-control, biological rep1 |
| GSM2534812 |
primary HSCs infected with shRNA-control, biological rep2 |
| GSM2534813 |
primary HSCs infected with lncRNA-shRNA1, biological rep1 |
| GSM2534814 |
primary HSCs infected with lncRNA-shRNA1, biological rep2 |
| GSM2534815 |
primary HSCs infected with lncRNA-shRNA3, biological rep1 |
| GSM2534816 |
primary HSCs infected with lncRNA-shRNA3, biological rep2 |
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| Relations |
| BioProject |
PRJNA378929 |
| SRA |
SRP101771 |
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