|
| Status |
Public on Nov 21, 2007 |
| Title |
Comparative transcriptomic profiling of unstimulated and inflamed HUVEC exposed to apple procyanidin oligomers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We used microarrays to investigate changes in gene expression of human vascular endothelial cells (HUVEC) exposed to an apple extract enriched in procyanidins of low-medium molecular weight (dp3.9) to determine possible protective effects induced by these plant derived compounds on the endothelial cells.
Keywords: Comparative gene expression, Control vs Treated cells (response to exposure with xenobiotics plant polyphenols)
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| |
|
| Overall design |
We used unstimulated and TNF-α-inflamed confluent monolayers of HUVEC exposed to low doses of oligomeric procyanidins extracted from apple, to determine whether these apple polyphenols exerted any protective effects on human endothelial cells.
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| |
|
| Contributor(s) |
Conesa MG, Cantalejo JG, Kroon PA |
| Citation(s) |
18979505 |
| Submission date |
Nov 20, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
María-Teresa García-Conesa |
| E-mail(s) |
mtconesa@cebas.csic.es
|
| Phone |
+ 34 968 396276
|
| Organization name |
CEBAS-CSIC
|
| Department |
Quality, Safety and Bioactivity of Plant Foods
|
| Street address |
Campus de Espinardo
|
| City |
Espinardo |
| State/province |
Murcia |
| ZIP/Postal code |
30100 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (12)
|
| GSM243712 |
HUVEC_dp3.9 (10 μg mL-1)_4h_biological rep1 |
| GSM243713 |
HUVEC_dp3.9 (10 μg mL-1)_4h_biological rep2 |
| GSM243714 |
HUVEC_dp3.9 (10 μg mL-1)_4h_biological rep3 |
| GSM243715 |
HUVEC_DMSO_4h_biological rep1 |
| GSM243716 |
HUVEC_DMSO_4h_biological rep2 |
| GSM243717 |
HUVEC_DMSO_4h_biological rep3 |
| GSM243718 |
HUVEC_dp3.9 (10μg mL-1)+TNF-α_6h_biological rep1 |
| GSM243719 |
HUVEC_dp3.9 (10μg mL-1)+TNF-α_6h_biological rep2 |
| GSM243720 |
HUVEC_dp3.9 (10μg mL-1)+TNF-α_6h_biological rep3 |
| GSM243721 |
HUVEC_DMSO+TNF-α_6h_biological rep1 |
| GSM243722 |
HUVEC_DMSO+TNF-α_6h_biological rep2 |
| GSM243723 |
HUVEC_DMSO+TNF-α_6h_biological rep3 |
|
| Relations |
| BioProject |
PRJNA103511 |
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