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Series GSE95317 Query DataSets for GSE95317
Status Public on Sep 04, 2018
Title Transcriptional profiling of irritant contact dermatitis (ICD) in a mouse model identifies specific patterns of gene expression and immune-regulation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Irritant contact dermatitis (ICD) is a non-immunological, cutaneous inflammatory response to a variety of triggers that requires no sensitization and accounts for up to 80% of occupational dermatitis cases. Numerous inflammatory cytokines play critical roles in the mechanism and severity of ICD, one being interleukin-6 (IL-6). Therefore, to investigate the influence of this pleotropic cytokine transcriptome analysis (MiSeq) was employed examining irritant-exposed and control skin samples from C57 and IL-6KO mice to gain a better understanding of the immunological mediators of ICD and what role IL-6 plays. Overall, this study offers new insight into the pathogenesis of ICD, indicates new mediators/markers that may influence the variability of responses to irritants and potential targets for therapeutic manipulation.
Overall design Examination of non-treated skin (C57 and IL-6KO, control samples), and 7 day BKC treated skin (C57-BKC and KO-BKC) in C57 and IL-6KO mouse skin. There are 3 replicates per group for a total of 12 samples and MiSeq analysis was performed.
Contributor(s) Luckett-Chastain L, Gallucci R
Citation(s) 30171875
Submission date Feb 23, 2017
Last update date Jan 27, 2019
Contact name Lerin Luckett-Chastain
Phone 405-271-6593
Organization name OUHSC
Department Pharmaceutical Science
Lab Gallucci
Street address 1110 N. Stonewall
City Oklahoma City
State/province OK
ZIP/Postal code 73117
Country USA
Platforms (1)
GPL16417 Illumina MiSeq (Mus musculus)
Samples (12)
GSM3091589 C57 rep1
GSM3091590 C57 rep2
GSM3091591 C57 rep3
BioProject PRJNA376616
SRA SRP100651

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE95317_C57_vs.C57-BKC.xlsx.gz 156.4 Kb (ftp)(http) XLSX
GSE95317_KO_vs.KO-BKC.xlsx.gz 109.0 Kb (ftp)(http) XLSX
GSE95317_RAW.tar 29.7 Mb (http)(custom) TAR (of TXT)
Raw data are available in SRA
Processed data are available on Series record
Processed data provided as supplementary file

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