|
| Status |
Public on Oct 31, 2017 |
| Title |
RNA-seq of HDAC2-disrupted 293FT cells by CRISPR-Cas9 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The transcriptional functions of HDAC1 and HDAC2 are largely viewed as repressive through their association in corepressor complexes, however, the unique functions and targets of HDAC2 are less well understood. We have utilized HDAC2-null cells to distinguish the role of HDAC2 in human cells and identify uniqye HDAC2 targets.
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| |
|
| Overall design |
HDAC2-null 293FT cells were created via CRISPR-Cas9 targeting and analyzed by RNA-seq for differential expression.
|
| |
|
| Contributor(s) |
Somanath P, Klein RH, Knoepfler P |
| Citation(s) |
28982113 |
| Submission date |
Feb 15, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Paul Knoepfler |
| E-mail(s) |
knoepfler@ucdavis.edu
|
| Organization name |
UC Davis School of Medicine
|
| Department |
Cell Biology and Human Anatomy
|
| Lab |
Knoepfler
|
| Street address |
1 Shields Ave
|
| City |
Davis |
| State/province |
CA |
| ZIP/Postal code |
95616 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA374887 |
| SRA |
SRP099865 |
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