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| Status |
Public on Mar 28, 2017 |
| Title |
The RNA helicase DDX39B regulates IL7R alternative splicing reducing the risk of Multiple Sclerosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose: The goal of this study is to investigate the role of DDX39B in RNA splicing
Methods: RNA-Seq splicing analysis of HeLa cells with experimentally induced DDX39B expression knockdown
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| Overall design |
DDX39B expression is reduced in HeLa cells by siRNAs. Effects on alternative RNA splicing are compared between knockdown and control cells.
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| Contributor(s) |
Galarza-Muñoz G, Briggs FB, Evsyukova I, Schott-Lerner GO, Kennedy EM, Nyanhete T, Wang L, Bergamaschi L, Widen SG, Tomaras GD, Ko DC, Bradrick SS, Barcellos LF, Gregory SG, Garcia-Blanco MA |
| Citation(s) |
28340352 |
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| Submission date |
Feb 09, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Mariano Garcia-Blanco |
| E-mail(s) |
maragarc@utmb.edu
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| Phone |
409-772-2271
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| Organization name |
The University of Texas Medical Branch
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| Street address |
301 University Blvd
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| City |
Galveston |
| ZIP/Postal code |
77555 |
| Country |
USA |
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| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA373878 |
| SRA |
SRP099127 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE94730_INCLUSION_LEVELS_FULL-Hsa6.tab.gz |
16.3 Mb |
(ftp)(http) |
TAB |
| GSE94730_NS.vs.D11.vast-tools.0.2.1.pdf |
2.4 Mb |
(ftp)(http) |
PDF |
| GSE94730_NS.vs.D11.vast-tools.0.2.1.tab.gz |
2.3 Mb |
(ftp)(http) |
TAB |
| GSE94730_NS.vs.D13.vast-tools.0.2.1.pdf |
1.2 Mb |
(ftp)(http) |
PDF |
| GSE94730_NS.vs.D13.vast-tools.0.2.1.tab.gz |
2.3 Mb |
(ftp)(http) |
TAB |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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