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Series GSE94729 Query DataSets for GSE94729
Status Public on Feb 07, 2020
Title Sexually dimorphic methylation of CD3+ T-lymphocyte DNA in offspring of overweight and obese mothers in a high risk, minority population in the Bronx
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary Maternal obesity impacts the health of offspring, increasing the risk of developing obesity and/or other metabolic dysregulation in childhood or later in life. Using a genome-wide methylation assay, we identified sex-dependent dysregulation of the methylome of CD3+ T-lymphocytes, a cell type that plays an important role in obesity and inflammatory diseases, in newborn offspring of overweight and obese mothers. Furthermore, the differentially methylated loci were targeted to regulatory regions of the genome, in imprinted genes and genes identified from GWAS as being related to type 2 diabetes and obesity.
Overall design DNA methylation was assessed globally at specific CpG sites in CD3+ T cell from 76 consenting women who delivered healthy, non-anomalous singleton AGA term neonates following an uncomplicated intrapartum course at the Weiler Division of Montefiore Medical Center.
Contributor(s) Charron MJ, Seki Y, Williams L, Fuloria M, Suzuki M
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Submission date Feb 09, 2017
Last update date Feb 08, 2020
Contact name Maureen J Charron
Organization name Albert Einstein College of Medicine
Department Biochemistry
Street address 1300 Morris Park Ave
City Bronx
State/province NY
ZIP/Postal code 10461
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (76)
GSM2481447 CBP1
GSM2481448 CBP2
GSM2481449 CBP3
BioProject PRJNA373885
SRA SRP099136

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Supplementary file Size Download File type/resource
GSE94729_RAW.tar 1.1 Gb (http)(custom) TAR (of BEDGRAPH)
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Raw data are available in SRA
Processed data provided as supplementary file

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