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Series GSE94557 Query DataSets for GSE94557
Status Public on Feb 23, 2018
Title Whole blood gene expression from lung transplanted patients with chronic lung allograft dysfunction
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Chronic lung allograft dysfunction (CLAD) limits the long term survival after lung transplantation. CLAD is diagnosed late on the decline in lung function, when any immuno-intervention is ineffective. Identification of early forerunners of CLAD is therefore essential to prevent the progression of the disease before irreversible damages to the allograft. We used large-scale gene expression profiling of whole blood cells to identify early biomarkers of Bronchiolitis Obliterans Syndrome (BOS), the main form of CLAD. Microarray experiments performed from 80 patients (40 stable (STA) and 40 BOS) identify 47 genes differentially expressed between STA and BOS recipients. An independent set of patients (13 STA, 11 BOS) was then used for external validation by qPCR. POU Class 2 Associating Factor 1 (POU2AF1), T-cell leukemia/lymphoma protein 1A (TCL1A) and B-cell lymphocyte kinase (BLK) genes were identified and validated as predictive markers of BOS more than 6 months before diagnosis with AUCs of 0.83, 0.77 and 0.78 respectively. These genes allow stratifying upon CLAD risk (log-rank test p<0.01) and could provide clinicians with new tools to improve follow-up and adapt treatment of patients likely to develop BOS.
Overall design This dataset represents gene expression profiling of periphal blood samples collected in PAXgene from 80 patients (40 stable (STA) and 40 BOS) using Agilent SurePrint G3 Human Gene Expression v3 8x60K Microarrays.
Contributor(s) Royer P, Danger R, Brouard S, Magnan A
Citation(s) 29375549
Submission date Feb 06, 2017
Last update date Nov 27, 2018
Contact name Richard Danger
Phone +33 2 40 08 75 65
Organization name CHU Nantes - INSERM- Nantes Universite
Department U1064
Street address 30 Boulevard Jean Monnet
City Nantes
ZIP/Postal code 44035
Country France
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (162)
GSM2478127 Stable_1
GSM2478128 Stable_10
GSM2478129 Stable_106
BioProject PRJNA371499

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE94557_RAW.tar 3.6 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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