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Series GSE94027 Query DataSets for GSE94027
Status Public on Nov 26, 2018
Title Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging
Organism Macaca mulatta
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary The abundance and function of circular RNAs (circRNAs) in mammalian brain have been reported, but their alterations in the biology of brain aging remain elusive. Here, using deep RNA profiling with linear RNA digestion by RNase R we explored a comprehensive map of changes in circRNA expression in rhesus macaque (macaca mulatta) brain in two age groups from adult (10 y) to aged (20 y) periods. Total 17,050 well expressed, stable circRNAs were identified. Cluster analysis reveals that dynamic changes in circRNA expression show the spatial-, sex- and age-biased specificities. On the basis of separate profiling of the RNAs, age-related circRNAs show differential correlation to host mRNA expression. Furthermore, two voltage-dependent L- and R-type calcium channel gene-derived circCACNA2D1 and circCACNA1E negatively regulate their host mRNA expression. Our results demonstrate the power of changes in circRNA expression to reveal insights into a potentially circRNA-mediated regulatory mechanism underlying the biology of brain aging.
Overall design Examination of 8 different brain regions in Rhesus Macaque across the two ages ( 10- and 20-year old )
Contributor(s) Li J, Zhang Y
Citation(s) 30245844, 32681011
Submission date Jan 24, 2017
Last update date Jul 27, 2020
Contact name dong chen
Organization name ablife
Street address GaoXin 2nd Road
City wuhan
State/province Hubei
ZIP/Postal code 430064
Country China
Platforms (1)
GPL21120 Illumina NextSeq 500 (Macaca mulatta)
Samples (32)
GSM2467238 PFC_10F
GSM2467239 PFC_10M
GSM2467240 PFC_20F
BioProject PRJNA363074
SRA SRP097707

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Supplementary file Size Download File type/resource
GSE94027_circRNA_TPM_by_sj_anno.txt.gz 2.3 Mb (ftp)(http) TXT
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