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Series GSE93408 Query DataSets for GSE93408
Status Public on Jan 11, 2018
Title Comparison of gene expression profilings between Mock-WS480, NonV50-OKS-SW480 and 2ndV50-OKS-SW480
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We have previously reported that colon cancer stem-like cells can be induced from human colon cancer cell lines by retrovirally introducing OCT3/4, SOX2 and KLF4, and we designated these cells as induced cancer stem cells (iCSCs). iCSCs showed significantly enhanced CSC properties in terms of the marker gene expression, sphere formation, chemoresistance and tumorigenicity. In the current study, we generated iCSCs using a polycistronic retroviral expression vector, and indicated that iCSCs-derived tissues in vitro are able to recapitulate human colon cancer tissues. To identify the molecular mechanisms that promote the properties of CSCs, we compared the global gene expression patterns of Mock-SW480 cells, non-V50 cells from 1st V50-OKS cells, and 2nd V50-OKS cells.
Overall design We extracted total RNA from 3 Mock-SW480 cells, 3 NonV50-cells from 1st V50-OKS cells and 3 2ndV50-OKS cells and hybridized them to Agilent gene expression microarrays.
Contributor(s) Ishida R
Citation(s) 28710230
Submission date Jan 11, 2017
Last update date Apr 12, 2018
Contact name Michiyo Koyanagi-Aoi
Organization name Kobe University
Street address Chuo-ku, Kusunoki-cho 7-5-1
City Kobe City
ZIP/Postal code 650-0017
Country Japan
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (9)
GSM2452817 Mock-SW480(Exp.1)
GSM2452818 Mock-SW480(Exp.2)
GSM2452819 Mock-SW480(Exp.3)
BioProject PRJNA360906

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93408_RAW.tar 28.0 Mb (http)(custom) TAR (of TXT)
Processed data provided as supplementary file

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