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Series GSE93216 Query DataSets for GSE93216
Status Public on Jan 06, 2017
Title 809094 Biomarker Identification in Fracture Healing (experiment #5149 Feb 2015)
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary The specific genes that distinguish normal fracture healing from abnormal healing or nonunion in humans are unknown. This study was an exploratory investigation of peripheral blood from acutely injured fracture patients collected over multiple days to compare normal healers, slow healers, and nonunion outcomes.
We used microarrays to do a global comparison between acutely injured (AI) subjects (AIS) vs age and sex matched healthy volunteers (HV) and chronic Nonunion (NU) patients.
 
Overall design AIS and NU were enrolled into the study upon presentation for fracture care. Blood was collected into Paxgene blood RNA tubes during the inpatient stay and during clinical follow up. HV were enrolled in parallel with a one-time blood sample collection into Paxgene blood RNA tubes. RNA was extracted from all samples applicable to this experiment. We explored the data with Partek Genomics suite using all samples at all time points to identify a panel of genes that is differentially expressed across groups to enable additional biomaker vetting.
 
Contributor(s) Mehta S, Horan AD
Citation(s) 31083145
Submission date Jan 05, 2017
Last update date Jul 18, 2019
Contact name Annamarie D Horan
E-mail(s) horana@pennmedicine.upenn.edu
Organization name University of Pennsylvania
Department Orthopaedic Surgery
Lab Division of Orthopaedic Trauma
Street address 3737 Market Street, 6th Floor
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (8)
GSM2448712 AIS-032-2
GSM2448713 AIS-040-3
GSM2448714 AIS-055-3
Relations
BioProject PRJNA360318

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93216_RAW.tar 6.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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