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Series GSE92946 Query DataSets for GSE92946
Status Public on Jan 16, 2017
Title Essential roles of Lamtor1 in CD4+ T cell-mediated autoimmunity
Organism Mus musculus
Experiment type Expression profiling by array
Summary Lamtor1 is a protein that is required for amino acid sensing and activation of mechanistic target of rapamycin complex 1 (mTORC1) at lysosomes. The critical role of Lamtor1 in macrophage polarization has been clarified recently. However, the role of Lamtor1 in adaptive immune system has not been investigated. Here we show that Lamtor1-deficient T cells showed markedly reduced IL-2 production, decreased mTORC1 activity, and decreased expression of purine-synthesis and lipid-synthesis enzymes.
Overall design The labeled cRNAs were hybridized on 4X44K ver.2 Agilent Whole Mouse Genome dual colour Microarrays (G4846A) in a dye swap experiment.
Contributor(s) Hosokawa T, Kimura T, Okuzaki D, Kumanogoh A
Citation(s) 28768723
Submission date Dec 27, 2016
Last update date Jan 19, 2018
Contact name Daisuke Okuzaki
Phone +81-6-6879-4935
Organization name Osaka univ.
Department Immunology Frontier Research Center
Lab Human Immunology (Single Cell Genomics)
Street address Yamadaoka 3-1
City Suita
State/province Osaka
ZIP/Postal code 565-0871
Country Japan
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (2)
GSM2440843 WT(cy3) vs KO(cy5) biological replicate 1
GSM2440844 KO(cy3) vs WT(cy5) biological replicate 1 dyeswap
BioProject PRJNA359121

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE92946_RAW.tar 37.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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