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Status |
Public on Jul 24, 2017 |
Title |
Transcriptome analysis to investigate the oncogenic TGF-β-Smad-Snail signaling pathway |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Our study shows that TGF-β signaling promotes tumorigenesis in the liver through upregulation of its target gene, Snail. We explored gene expression changes in tumors following TGF-β inhibition, and tumors ectopically expressing Snail with the TGF-β inhibition. RNA samples were harvested from tumors expressing Smad7 (S7HP tumors), firefly luciferase (LHP tumors), and Smad7 plus Snail (S7HP+Snail), respectively. Differentially expressed genes were investigated in LHP and S7HP+Snail tumors, compared with S7HP tumors.
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Overall design |
mRNA profiles of LHP, S7HP, and S7HP+Snail tumors were generated, in triplicate, by RNA-sequencing
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Contributor(s) |
Moon H, Cho KJ, Ro SW |
Citation(s) |
28734833 |
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Submission date |
Nov 18, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Simon Weonsang Ro |
E-mail(s) |
simonr@yuhs.ac
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Phone |
+82-2-2228-0811
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Organization name |
Yonsei University College of Medicine
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Department |
Institute of Gastroenterology
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Street address |
Yonsei-ro 50-1
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City |
Seoul |
ZIP/Postal code |
03722 |
Country |
South Korea |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (9)
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Relations |
BioProject |
PRJNA354391 |
SRA |
SRP093717 |