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Series GSE90024 Query DataSets for GSE90024
Status Public on Jul 24, 2017
Title Transcriptome analysis to investigate the oncogenic TGF-β-Smad-Snail signaling pathway
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Our study shows that TGF-β signaling promotes tumorigenesis in the liver through upregulation of its target gene, Snail. We explored gene expression changes in tumors following TGF-β inhibition, and tumors ectopically expressing Snail with the TGF-β inhibition. RNA samples were harvested from tumors expressing Smad7 (S7HP tumors), firefly luciferase (LHP tumors), and Smad7 plus Snail (S7HP+Snail), respectively. Differentially expressed genes were investigated in LHP and S7HP+Snail tumors, compared with S7HP tumors.
Overall design mRNA profiles of LHP, S7HP, and S7HP+Snail tumors were generated, in triplicate, by RNA-sequencing
Contributor(s) Moon H, Cho KJ, Ro SW
Citation(s) 28734833
Submission date Nov 18, 2016
Last update date May 15, 2019
Contact name Simon Weonsang Ro
Phone +82-2-2228-0811
Organization name Yonsei University College of Medicine
Department Institute of Gastroenterology
Street address Yonsei-ro 50-1
City Seoul
ZIP/Postal code 03722
Country South Korea
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (9)
GSM2395813 LHP tumor #2
GSM2395814 LHP tumor #3
GSM2395815 LHP tumor #6
BioProject PRJNA354391
SRA SRP093717

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE90024_RAW.tar 1.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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