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| Status |
Public on Nov 10, 2016 |
| Title |
Differential gene expressions in the heart of hypertrophic cardiomyopathy patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Differential gene expressions were constructed through expression profiling of a total of 20,127 genes in the heart tissue of hypertrophic cardiomyopathy patients, then 1799 significant differential genes were filtered based on the criteria (p<0.05 and fold change > 1.5), respectively.
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| Overall design |
In the study presented here, human hypertrophic heart tissue samples were obtained from patients previously diagnosed with hypertrophic cardiomyopathy, undergoing septal myectomy surgery (n=5). Control samples were obtained from normal heart donor left ventricles (n=4). The heart tissues were collected and performed transcriptome analysis by RNA-sequencing. Compared to normal heart, 1799 significant differentially expressed genes (filtering criteria p<0.05, fold change>1.5) were identified 7-days or 28 days post-Ang II infusion.
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| Contributor(s) |
Li Y, Guo H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 09, 2016 |
| Last update date |
Apr 16, 2021 |
| Contact name |
李 玉琳 |
| Organization name |
Beijing Institute of Heart Lung and Blood Vessel Diseases
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| Street address |
2 Anzhen Rd, Chaoyang District,
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| City |
Beijing |
| ZIP/Postal code |
100029 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA352990 |
| SRA |
SRP093240 |
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