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Series GSE87670 Query DataSets for GSE87670
Status Public on Oct 06, 2018
Title Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 T cell differentiation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary A key mechanism to eliminate pathogens from the body is the physical internalization (phagocytosis) and degradation of microbes by specialized cells of the immune system including neutrophils, macrophages, and dendritic cells. Phagocytosis not only eliminates potentially harmful pathogens, but also provides information about the “type” of microbe encountered, and helps to orchestrate an appropriate adaptive immune response. Certain pathogens, including filamentous fungi and parasite worms (helminths), exceed the size limit for phagocytosis. In this study we show that when dendritic cells encounter pathogens that are too large to internalize, or when phagocytosis of small microbes is blocked, dendritic cells adopt an activation profile that allows them to orchestrate an adaptive immune response commonly associated with tissue repair and anti-helminth immunity.
Overall design Examination of mice bone marrow derived dendritic cell behavior with different physical forms of C.albicans
Contributor(s) Underhill DM, Wheeler ML, Paterson MJ, Wolf AJ, Gargus M, Tang J, Gangalapudi V
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Submission date Oct 05, 2016
Last update date May 15, 2019
Contact name vineela gangalapudi
Organization name Cedars- sinai Medical center
Department Biomedical sciences
Lab Genomics Core
Street address 8723 Alden drive
City Los Angeles
State/province CALIFORNIA
ZIP/Postal code 90048
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (8)
GSM2338054 No stimulation 1
GSM2338055 No stimulation 2
GSM2338056 C.alb. Yeast 1
BioProject PRJNA345509
SRA SRP090904

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE87670_Wheeler_mouse_counts.xlsx 1.3 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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