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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 24, 2018 |
| Title |
Circadian Clock Protein CRY Regulates Autoimmunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The circadian system regulates numerous physiological processes including the adaptive immune system. Here we show that mice deficient for the circadian genes Cry1 and Cry2, (DKO) display an autoimmune phenotype including higher serum IgG concentration, presence of serum anti-nuclear antibodies, precipitation of IgG, IgM and complement 3 in glomeruli, and massive infiltrations of leukocytes into the lung and kidney. Activation of Cry DKO splenic B cells elicited markedly enhanced and prolonged tyrosine phosphorylation of cellular proteins compared to cells from control mice, suggesting that over activation of the BCR signaling pathway may contribute to autoimmunity in the Cry DKO mice. Expression of C1q, deficiency of which contributes to the pathogenesis of Systemic lupus erythematosus (SLE), was significantly downregulated in Cry DKO B cells. This suggests that B cell development, BCR signaling pathway and C1q expression may be under direct circadian control and dysregulation of which contributes to autoimmunity.
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| Overall design |
Comparison of wild-type and Cry1/2 double KO BM cells
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| Contributor(s) |
Yu RT, Cao Q |
| Citation(s) |
29109286 |
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| Submission date |
Sep 29, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Ruth T Yu |
| Organization name |
Salk Institute
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| Department |
Gene Expression Lab
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| Lab |
Ronald Evans
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| Street address |
10010 N Torrey Pines Rd
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA344857 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE87467_RAW.tar |
21.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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