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Series GSE87382 Query DataSets for GSE87382
Status Public on Sep 28, 2017
Title Dietary medium-chain saturated fatty acids induce gene expression of energy metabolism-related pathways in adipose tissue of abdominally obese subjects
Organism Homo sapiens
Experiment type Expression profiling by array
Summary High MC-SFA intake resulted in a downregulation of gene expression of pathways related to complement system and inflammation, and an upregulation of gene expression of pathways related to citric acid cycle, electron transport chain and lipid metabolism in adipose tissue. Based on our results, we hypothesize that the beneficial effects of MC-SFAs on prevention of fat accumulation may be mediated by increases in gene expression related to energy metabolism in the adipose tissue. Additionally, decreases in inflammation-related gene expression in the adipose may potentially have beneficial effects in relation to cardiometabolic diseases.
Overall design In this 12 week, randomized, double-blind, diet intervention study, participants consumed 60 g milk protein (whey or casein) and 63 g milk fat (high MC-SFA or low MC-SFA) daily in a 2 by 2 factorial design. We used microarrays to measure whole genome gene expression in adipose tissue in a subpopulation of 12 participants, 6 in the casein + low MC-SFA group and 6 in the casein + high MC-SFA group, before and after intervention.
Contributor(s) Matualatupauw JC, Bohl M, Gregersen S, Hermansen K, Afman LA
Citation(s) 28529330
Submission date Sep 27, 2016
Last update date Jan 03, 2018
Contact name Juri C Matualatupauw
Organization name Wageningen University
Department Human Nutrition
Street address PO Box 17
City Wageningen
ZIP/Postal code 6700 AA
Country Netherlands
Platforms (1)
GPL11532 [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Samples (24)
GSM2330001 SubjectID 22, low MC-SFA, before
GSM2330002 SubjectID 22, low MC-SFA, after
GSM2330003 SubjectID 89, low MC-SFA, before
BioProject PRJNA344580

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Supplementary file Size Download File type/resource
GSE87382_RAW.tar 104.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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