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| Status |
Public on Aug 10, 2007 |
| Title |
Effects of TGF-β1 on expression profile of human pulp and odontoblasts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Transforming growth factor beta 1 (TGF-β1) is the most extensively studied growth factor in dentin-pulp complex, with pleiotropic effects on pulp response and healing. Our main objective was to analyze the expression profile of pulp tissue and odontoblasts, and the effects of TGF-β1 on these profiles in cultured human pulp and odontoblasts with a specific interest in the anti- and pro-inflammatory cytokines.
Keywords: Response to TGF-β1 treatment
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| Overall design |
Pulp tissues and odontoblasts were cultured for different time periods, and microarray was performed to both cultured and native samples to detect the effects of TGF-β1. Expression of various interleukins (IL) were confirmed by RT-PCR, and in +/- TGF-β1 treated pulps also by antibody array.
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| Contributor(s) |
Pääkkönen V, Vuoristo JT, Salo T, Tjäderhane L |
| Citation(s) |
17889552 |
| Submission date |
Aug 09, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Virve Pääkkönen |
| E-mail(s) |
virve.paakkonen@oulu.fi
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| Organization name |
University of Oulu
|
| Department |
Institute of Dentistry
|
| Street address |
Aapistie 3
|
| City |
Oulu |
| ZIP/Postal code |
90014 |
| Country |
Finland |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA101987 |
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