|
| Status |
Public on Oct 31, 2016 |
| Title |
Transcriptional profiles of virus-specific CD8+ T cells from control or anti-PD-L1-treated LCMV-Clone 13 infected mice one day or 18-29 weeks after treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-Seq analysis was used to study the profile of exhausted Tcells and how anti-PD-L1 treatment changed the properties of these cells short term & long term after treatment
|
| |
|
| Overall design |
Transcriptional profiles of virus-specific CD8+ T cells from control or anti-PD-L1-treated LCMV-Clone 13 infected mice one day or 18-29 weeks after treatment
|
| |
|
| Contributor(s) |
PAUKEN KE, Wherry EJ |
| Citation(s) |
27789795 |
| BioProject |
PRJNA342327 |
| Submission date |
Sep 13, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
E JOHN WHERRY |
| Organization name |
University of Pennsylvania
|
| Department |
Systems Pharmacology and Translational Therapeutics,Institute for Immunology
|
| Street address |
421 Curie Blvd,354 BRB II/III
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (13)
|
| GSM2309810 |
RNA-seq of CD8 T cells from spleen-Naïve, 1 |
| GSM2309811 |
RNA-seq of CD8 T cells from spleen-Naïve, 2 |
| GSM2309812 |
RNA-seq of CD8 T cells from spleen-exhausted_untreated, 1 |
| GSM2309813 |
RNA-seq of CD8 T cells from spleen-exhausted_untreated, 2 |
| GSM2309814 |
RNA-seq of CD8 T cells from spleen-exhausted_untreated, 3 |
| GSM2309815 |
RNA-seq of CD8 T cells from spleen-exhausted_PD-L1, 1 |
| GSM2309816 |
RNA-seq of CD8 T cells from spleen-exhausted_PD-L1, 2 |
| GSM2309817 |
RNA-seq of CD8 T cells from spleen-exhausted_PD-L1, 3 |
| GSM2309818 |
RNA-seq of CD8 T cells from spleen-exhausted_PD-L1, 4 |
| GSM2309819 |
RNA-seq of CD8 T cells from spleen-exhausted_untreated-day235 |
| GSM2309820 |
RNA-seq of CD8 T cells from spleen-exhausted_untreated-day160 |
| GSM2309821 |
RNA-seq of CD8 T cells from spleen-exhausted_PD-L1-day235 |
| GSM2309822 |
RNA-seq of CD8 T cells from spleen-exhausted_PD-L1-day160 |
|
| Relations |
| SRA |
SRP087641 |
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