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Series GSE86797 Query DataSets for GSE86797
Status Public on Oct 31, 2016
Title Epigenetic inflexibility of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Upon PD-1 pathway blockade,the epigenetic landscape of exhausted cells was only minimally remodeled consistent with lineage commitment and re-exhaustion of these cells over time.
 
Overall design Epigenetic profiling of Exhausted T cells & examinaton of epigenetic changes associated with PD-pathway blockade by ATAC-seq using the mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV)
 
Contributor(s) Pauken KE, Khan O, Sammons M, Manne SK, Wherry EJ
Citation(s) 27789795
Submission date Sep 10, 2016
Last update date May 15, 2019
Contact name E JOHN WHERRY
Organization name University of Pennsylvania
Department Systems Pharmacology and Translational Therapeutics,Institute for Immunology
Street address 421 Curie Blvd,354 BRB II/III
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (10)
GSM2308856 Naive_cells_ATAC-Seq 1
GSM2308857 Naive_cells_ATAC-Seq 2
GSM2308858 Effector_cells_ATAC-Seq 1
Relations
BioProject PRJNA342526
SRA SRP088651

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE86797_RAW.tar 7.7 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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