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Series GSE86780 Query DataSets for GSE86780
Status Public on Nov 20, 2017
Title Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In support of our manuscript investigating the roles of ILCs and T cells in the maintenance of gut hoemostasis, we have performed RNAseq on terminal illeum of mice lacking either all adaptive immune cells (RAG1 -/-), deficient in T cells (TCRalpha -/-), or deficient in T cells but co-housed with wild-type mice and RAG1 -/- mice.
Overall design Tissues from three mice per group were analysed, and the following comparisions were made: RAG1-/- vs. WT C57BL/6 and TCRa-/- co-housed vs TCRa-/- seperately housed. Differential expression genes were identified at 1% FDR using DESeq2.
Contributor(s) Mao K, Martins AJ, Germain RN
Citation(s) 29364878
Submission date Sep 09, 2016
Last update date Sep 05, 2023
Contact name Andrew Martins
Organization name Yale School of Medicine
Department Immunobiology
Street address 100 College Street Rm 1155
City New Haven
State/province Connecticut
ZIP/Postal code 06510
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (12)
GSM2308664 RAG1x3163
GSM2308665 RAG1x3164
GSM2308666 RAG1x3168
BioProject PRJNA342497
SRA SRP087889

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Supplementary file Size Download File type/resource
GSE86780_genes.counts.txt.gz 2.3 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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