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Series GSE85995 Query DataSets for GSE85995
Status Public on Jun 13, 2017
Title Function and hormonal regulation of GATA3 in human first trimester placentation
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The transcription factor GATA3 is down regulated by estrogen and plays a role in trophoblast cell function and placentation.
Overall design To identify downstream genes involved in GATA3 regulation of trophoblast function, we performed RNA sequencing of GATA3 knockdown HTR8/SVneo cells. First, GATA3 expression in HTR8/SVneo cells were knocked down by siRNA transfection and the reduction in GATA3 expression confirmed. Then, gene expression profiles of GATA3 knockdown cells were determined using RNA sequencing on the Illumina NextSeq 500.
Contributor(s) Lee B, Kroener LL, Xu N, Wang ET, Banks A, Williams J, Goodarzi MO, Chen YI, Tang J, Wang Y, Gangalapudi V, Pisarska MD
Citation(s) 27733378
Submission date Aug 24, 2016
Last update date Oct 11, 2021
Contact name AGCT Core
Organization name Cedars Sinai Medical Center
Department BMS
Street address 8687 Melrose Ave, PDC B230
City West Hollywood
State/province CA
ZIP/Postal code 90069
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (6)
GSM2290285 C1-48h
GSM2290286 C2-48h
GSM2290287 C3-48h
BioProject PRJNA339963

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85995_all_samples.counts.txt.gz 514.5 Kb (ftp)(http) TXT
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Raw data provided as supplementary file
Processed data are available on Series record

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