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Series GSE85835 Query DataSets for GSE85835
Status Public on Jul 26, 2017
Title Transgenerational inheritance of mitochondrial stress adaptation in C. elegans
Organism Caenorhabditis elegans
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Using Caenorhabditis elegans to investigate environmental cues-induced mitochondrial dysfunction, we found that exposure to electron transport chain (ETC) inhibitors at the parental generation initiates the transmission of heritable information to descendants and make descendants stress-adaptive. This mitochondrial stress adaptation phenotype can persist for at least three generations. Animals lacking histone H3K4me3 chromatin modifiers, or the methyltransferase of N6-methyldeoxyadenosine (6mA), lose the ability to initiate stress adaptation in progeny. H3K4me3 plays a role upstream of 6mA, while both mark promoter regions of mitochondrial unfolded protein response (UPR mt ) genes and activate the UPR mt pathway to alleviate mitochondrial damage.
 
Overall design Profile H3K4me3 occupancy in whole body from L3-L4 mix C. elegans, worms were treated with antimycin A (AA) or not treated (NT).
 
Contributor(s) Ma C, Niu R, Shao L, Peng Y, Wang Y, Jia G, He A, He C, Liu Y
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Submission date Aug 19, 2016
Last update date May 15, 2019
Contact name Yong Peng
E-mail(s) yongp@outlook.com
Organization name University of Chicago
Department Department of Chemistry
Lab Chuan He
Street address 929 E 57th Street
City Chicago
State/province IL
ZIP/Postal code 60615
Country USA
 
Platforms (1)
GPL18245 Illumina HiSeq 2500 (Caenorhabditis elegans)
Samples (6)
GSM2285294 WT_AA_H3K4me3_Rep1
GSM2285295 WT_AA_H3K4me3_Rep2
GSM2285296 WT_AA_Input_Rep1
Relations
BioProject PRJNA339523
SRA SRP082400

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Supplementary file Size Download File type/resource
GSE85835_RAW.tar 412.3 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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