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Series GSE85594 Query DataSets for GSE85594
Status Public on Aug 16, 2016
Title A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary The Kashmiri population is an ethno-linguistic group that resides in the Kashmir Valley in northern India. A longstanding hypothesis is that this population derives ancestry from Jewish and/or Greek sources. There is historical and archaeological evidence of ancient Greek presence in India and Kashmir. Further, some historical accounts suggest ancient Hebrew ancestry as well. To date, it has not been determined whether signatures of Greek or Jewish admixture can be detected in the Kashmiri population. Using genome-wide genotyping and admixture detection methods, we determined there are no significant or substantial signs of Greek or Jewish admixture in modern-day Kashmiris. The ancestry of Kashmiri Tibetans was also determined, which showed signs of admixture with populations from northern India and west Eurasia. These results contribute to our understanding of the existing population structure in northern India and its surrounding geographical areas.
 
Overall design DNA was collected from 15 Kashmiri individuals from the Kashmir Valley who provided written consent. The families of these individuals have resided in the Kashmir Valley for at least three generations and have no history of marriages outside of the valley or to a non-Kashmiri. Sixteen Kashmiri Tibetans from Srinagar, India, who have Tibetan ancestry and now practice Islam, were also genotyped. We performed further genotyping on a previously undescribed population of 32 first- and second-generation Tibetan exiles in McLeod Ganj, which included two individuals from the Tibetan Children’s Village, to serve as population references. These individuals were then genotyped for single nucleotide polymorphisms (SNPs) using the Affymetrix Genome-Wide Human SNP Array 6.0.
 
Contributor(s) Downie JM, Tashi T, Lorenzo FR, Feusier JE, Mir H, Prchal JT, Jorde LB, Koul PA
Citation(s) 27490348
Submission date Aug 15, 2016
Last update date Nov 27, 2018
Contact name Lynn Jorde
E-mail(s) lbj@genetics.utah.edu
Organization name University of Utah
Department Human Genetics
Lab Jorde
Street address 15 S 2030 E Room #5100
City Salt Lake City
State/province UT
ZIP/Postal code 84112
Country USA
 
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (47)
GSM2278910 Kashmiri_sample_01
GSM2278911 Kashmiri_sample_02
GSM2278912 Kashmiri_sample_06
Relations
BioProject PRJNA338914

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85594_RAW.tar 1.9 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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