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Series GSE85440 Query DataSets for GSE85440
Status Public on Aug 06, 2019
Title Inhibition of Tumor Growth and Metastasis by EMMPRIN Multiple Antigenic Peptide (MAP) Vaccination Is Mediated by Immune Modulation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We report here that a EMMPRINs-specific cancer peptide vaccination, where the peptide was modified and synthesied as a multiple antigenic peptide (MAP), significantly inhibited tumor growth and metastases. Specifically, we describe changes in the gene expression profile as assessed by RNAseq in tumors derived from mice implanted with the colon tumorigenic carcinoma (CT26 cells), and vaccinated with either a control scrambled multiple antigenic peptide (Scr-MAP) or with an epitope-specific EMMPRIN multiple antigenic peptide (designated 161-MAP).
Overall design Toral RNA from tumors from 3 mice in each group (Scr-MAP and 161-MAP vaccinated) were extracted, and RNAseq analysis revealed differentially expressed genes (DEGs).
Contributor(s) Rahat MA
Citation(s) 28197388
Submission date Aug 10, 2016
Last update date Aug 06, 2019
Contact name Michal (Miki) A. Rahat
Organization name Carmel Medical Center & Technion-Israel Institute of Technology
Department Immunology, Faculty of Medicine
Lab Immunotherapy Lab
Street address 7 Michal st.,
City Haifa
ZIP/Postal code 3436212
Country Israel
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM2267032 Liat-2 (Scr-MAP)
GSM2267033 Liat-5 (Scr-MAP)
GSM2267034 Liat-126 (Scr-MAP)
BioProject PRJNA338459
SRA SRP081234

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85440_control_vs_comparison.deseq.counts.txt.gz 262.4 Kb (ftp)(http) TXT
GSE85440_genes.fpkm.txt.gz 710.9 Kb (ftp)(http) TXT
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