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Series GSE85411 Query DataSets for GSE85411
Status Public on May 30, 2018
Title Gene expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice.
Organism Mus musculus
Experiment type Expression profiling by array
Summary We compared mRNA expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice, using DNA microarray analysis. In S1pr2-/- macrophages, 398 genes showed decreases to less than 50% of the levels in wild-type macrophages. In contrast, 122 genes showed more than 2.0-fold increases in S1pr2-/- macrophages compared with wild-type macrophages. The downregulated genes in S1pr2-/- mice included the following potentially fibrosis–related genes: profibrotic cytokines, chemokines, and the markers characteristic of classically activated (M1) and alternatively activated (M2) macrophages.
 
Overall design BALF cells from wild-type and S1pr2-/- mice on day 22 after bleomycin administration were collected and analyzed. Two independent experiments were performed.
 
Contributor(s) Takuwa Y, Okamoto Y
Citation(s) 29782549
Submission date Aug 10, 2016
Last update date May 30, 2018
Contact name Takumi Nishiuchi
E-mail(s) tnish9@staff.kanazawa-u.ac.jp
Organization name Kanazawa University
Street address 13-1 Takaramachi
City Kanazawa
ZIP/Postal code 920-0934
Country Japan
 
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (4)
GSM2266370 Wt_bleomycin#1
GSM2266371 Wt_bleomycin#2
GSM2266372 S1P2-KO_bleomycin#1
Relations
BioProject PRJNA338392

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85411_RAW.tar 8.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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