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Series GSE85377 Query DataSets for GSE85377
Status Public on Jul 06, 2017
Title Spatiotemporal- and sex-specific Dynamics of lncRNA expression links to brain development and aging in Rhesus Macaque (RNA-seq)
Organism Macaca mulatta
Experiment type Expression profiling by high throughput sequencing
Summary Dynamic remodeling in architecture and function of mammalian brain, especially in primate, rely on a precisely orchestrated molecular and cellular regulation at distinct levels. Here, we applied comprehensive RNA-seq and CAGE-Seq analysis to characterize dynamics of lncRNA expression in Rhesus macaque brain across postnatal development and aging. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age and sex specificities respectively. Highly spatiotemporal- and sex-specific dynamic changes in lncRNA but mRNA expression and the negative correlation between lncRNAs and mRNAs, functionally associate with brain development and aging, especially in the neocortex. Together with in situ hybridization (ISH) and quantitative real time-PCR (qRT-PCR) data, our findings provide an initial insight into spatial-, age- and sex-related dynamics of lncRNA expression during postnatal brain development and aging in macaque, implying that high dynamics of lncRNA expression might represent a previously unappreciated regulatory system in shaping brain architecture and function.
Overall design Examination of 8 different brain regions in Rhesus Macaque across the four ages (1-, 4-, 10- and 20-years old).
Contributor(s) Li J, Zhang Y
Citation(s) 28687705, 32681011
Submission date Aug 09, 2016
Last update date Jul 27, 2020
Contact name Dong Chen
Organization name ABLife, Inc.
Department Center for Genome Analysis
Street address 388 GaoXin 2nd Road, East Lake Hi-Tech Development Zone
City Wuhan
State/province Hubei
ZIP/Postal code 430075
Country China
Platforms (2)
GPL14954 Illumina HiSeq 2000 (Macaca mulatta)
GPL21120 Illumina NextSeq 500 (Macaca mulatta)
Samples (64)
GSM2266015 CB 1F RNA_seq
GSM2266016 CB 1M RNA_seq
GSM2266017 CB 4F RNA_seq
This SubSeries is part of SuperSeries:
GSE87182 Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain
BioProject PRJNA338300
SRA SRP081159

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Supplementary file Size Download File type/resource
GSE85377_All_sample_merged_RPKM_ed.xlsx 10.4 Mb (ftp)(http) XLSX
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Processed data are available on Series record

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