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Series GSE84877 Query DataSets for GSE84877
Status Public on Jul 27, 2016
Title Effect of from Human Umbilical Vein Endothelial Cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We profiled global gene expression in primary human umbilical vein endothelial cells to determine the gene expression changes associated with knocking down PKM2 and p53. We identified a p53 dependent transcriptional response that remodels metabolism in cells lacking p53, thus limiting cell growth.
Overall design Human Umbilical Vein Endothelial Cells were transfected with siRNA duplexes targeting PKM2 and / or p53, RNA was extracted and subjected to RNA sequencing
Contributor(s) Stone O, Stainier D
Citation(s) 30301887
Submission date Jul 26, 2016
Last update date May 15, 2019
Contact name Oliver Andrew Stone
Phone +4960327051302
Organization name Max Planck Institute
Department Developmental Genetics
Lab Stainier
Street address Ludwigstr 43
City Bad Nauheim
ZIP/Postal code 61231
Country Germany
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (12)
GSM2252986 scr_1
GSM2252987 scr_2
GSM2252988 scr_3
BioProject PRJNA335410
SRA SRP079926

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Supplementary file Size Download File type/resource
GSE84877_matrix.txt.gz 941.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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