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| Status |
Public on Dec 01, 2017 |
| Title |
Glucose inhibits cardiac maturation through nucleotide biosynthesis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In summary, we discovered (1) that glucose dose-dependently inhibits cardiac maturation in vitro and in vivo, (2) that the maturation-inhibitory effect is dependent on nucleotide biosynthesis via the PPP, (3) that the developing heart accomplishes glucose deprivation condition by limiting the glucose uptake at late gestational stages during normal embryogenesis, and (4) that perturbation of the glucose deprivation in gestational diabetes affects natural cardiomyocyte maturation and potentially contributes to congenital heart disease.
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| Overall design |
Three different samples, three replicates each
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| Contributor(s) |
Nakano H, Minami I, Braas D, Wu X, Vergnes L, Pappoe H, Morselli M, Fu K, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A |
| Citation(s) |
29231167, 30240284 |
| Submission date |
Jul 25, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
matteo pellegrini |
| E-mail(s) |
matteop@mcdb.ucla.edu
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| Phone |
310 825-0012
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| Organization name |
UCLA
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| Street address |
610 charles young drive east
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| City |
los angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA331184 |
| SRA |
SRP079700 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE84814_RAW.tar |
990.0 Kb |
(http)(custom) |
TAR (of TXT) |
| GSE84814_glucose_normalize.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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