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Series GSE84814 Query DataSets for GSE84814
Status Public on Dec 01, 2017
Title Glucose inhibits cardiac maturation through nucleotide biosynthesis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary In summary, we discovered (1) that glucose dose-dependently inhibits cardiac maturation in vitro and in vivo, (2) that the maturation-inhibitory effect is dependent on nucleotide biosynthesis via the PPP, (3) that the developing heart accomplishes glucose deprivation condition by limiting the glucose uptake at late gestational stages during normal embryogenesis, and (4) that perturbation of the glucose deprivation in gestational diabetes affects natural cardiomyocyte maturation and potentially contributes to congenital heart disease.
Overall design Three different samples, three replicates each
Contributor(s) Nakano H, Minami I, Braas D, Wu X, Vergnes L, Pappoe H, Morselli M, Fu K, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A
Citation(s) 29231167, 30240284
Submission date Jul 25, 2016
Last update date May 15, 2019
Contact name matteo pellegrini
Phone 310 825-0012
Organization name UCLA
Street address 610 charles young drive east
City los angeles
State/province CA
ZIP/Postal code 90095
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (9)
GSM2251702 G0-1
GSM2251703 G0-2
GSM2251704 G0-3
BioProject PRJNA331184
SRA SRP079700

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE84814_RAW.tar 990.0 Kb (http)(custom) TAR (of TXT)
GSE84814_glucose_normalize.txt.gz 1.6 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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