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Series GSE84618 Query DataSets for GSE84618
Status Public on Mar 07, 2018
Title Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-associated neurodegeneration. Here we compared the genome-wide enrichment of H4K16ac in the lateral temporal lobe of AD individuals against both younger and elderly cognitively normal controls. We find that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. Our analysis highlights the presence of three classes of AD-related changes having distinctive functional roles. Furthermore, we discover an association between the genomic locations of significant H4K16ac changes with genetic variants (SNPs) identified in prior AD genome-wide association studies (GWAS) and with expression quantitative trait loci (eQTLs). Our results establish the basis for an epigenetic link between aging and AD.
Overall design ChIP-seq of H4K16ac in healthy and diseased human brains; using 9 young healthy brains (Young), 10 aged healthy brains (Old), and 12 aged diseased brains (AD); H4K16ac and input are included for each sample
Contributor(s) Nativio R, Donahue G, Berson A, Gosai SJ, Toledo JB, Amlie-Wolf A, Tuzer F, Torres C, Trojanowski JQ, Wang L, Gregory BD, Johnson FB, Bonini NM, Berger SL
Citation(s) 29507413
Submission date Jul 20, 2016
Last update date May 15, 2019
Contact name Gregory Donahue
Organization name The University of Pennsylvania
Department Cell & Developmental Biology
Lab Zaret Lab
Street address 3400 Civic Center Blvd, Bldg 421
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (62)
GSM2806152 1-15T.H4K16ac.Young
GSM2806153 2-12A.H4K16ac.Young
GSM2806154 3-17T.H4K16ac.Young
This SubSeries is part of SuperSeries:
GSE104705 Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease
BioProject PRJNA330668
SRA SRP078988

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Supplementary file Size Download File type/resource
GSE84618_Age-Disregulated_H4K16ac_Changes.hg19.bed.gz 111.9 Kb (ftp)(http) BED
GSE84618_Age-Regulated_H4K16ac_Changes.hg19.bed.gz 73.4 Kb (ftp)(http) BED
GSE84618_Disease-Specific_H4K16ac_Changes.hg19.bed.gz 89.8 Kb (ftp)(http) BED 4.0 Gb (ftp)(http) BW 3.5 Gb (ftp)(http) BW 2.2 Gb (ftp)(http) BW
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